{"id":"W2315334721","doi":"10.1021/jm301892f","title":"Identification of Selective Inhibitors for Human Neuraminidase Isoenzymes Using C4,C7-Modified 2-Deoxy-2,3-didehydro-<i>N</i>-acetylneuraminic Acid (DANA) Analogues","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University; Alberta Glycomics Centre; Université de Montréal; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Isozyme; Chemistry; Neuraminidase; Sialic acid; Sialidase; Enzyme; Biochemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313412,0.0006722141,0.0004741957,0.0003097603,0.0001367836,0.0002751894,0.0004300932,0.000328437,0.0006645027],"category_scores_gemma":[0.0001623062,0.0001959251,0.0003589667,0.0002249485,0.0002200742,0.0002294332,0.0002852366,0.0004998753,0.0003293118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005234565,"about_ca_system_score_gemma":0.0003324138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007628262,"about_ca_topic_score_gemma":0.001297344,"domain_scores_codex":[0.9998585,0.00002541745,0.00001310727,0.0000266614,0.00003436482,0.00004195255],"domain_scores_gemma":[0.9999307,0.00001095438,0.00001331534,0.000006242644,0.00001665283,0.00002196191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004005693,0.0002331127,0.0003101074,0.000186591,0.00004408714,0.0002063215,0.00004313797,0.001405531,0.9826696,0.0005263062,0.000238715,0.01373609],"study_design_scores_gemma":[0.0001504677,0.001797369,0.0008552035,0.00001527248,0.00005344006,0.0002767653,0.00001471281,0.001693384,0.9896063,0.00007987041,0.005440239,0.00001706663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745169,0.01043956,0.007970247,0.0001530039,0.00007877582,0.0004171618,0.0005939487,0.0001218131,0.005708662],"genre_scores_gemma":[0.9784051,0.007604156,0.008898455,0.0001923756,0.00002413226,0.0002143787,0.001215976,0.00003156085,0.003413853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007628262,"threshold_uncertainty_score":0.003798008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138433452342346,"score_gpt":0.3161213327952784,"score_spread":0.294736998271855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}