{"id":"W2315423922","doi":"10.1021/ar300072g","title":"The Cation−π Interaction at Protein–Protein Interaction Interfaces: Developing and Learning from Synthetic Mimics of Proteins That Bind Methylated Lysines","year":2012,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Methylation; Demethylase; Chemistry; Epigenetics; Lysine; Methyltransferase; Biochemistry; Computational biology; Biology; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008690596,0.0001272022,0.0001514736,0.00008645625,0.0001396967,0.00003537297,0.0001900753,0.0002077108,0.00001942332],"category_scores_gemma":[0.001275988,0.0001025758,0.00004407348,0.0001987098,0.0002376861,0.00004138709,0.0003006403,0.0003515177,0.000005384158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688062,"about_ca_system_score_gemma":0.00008718912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003685928,"about_ca_topic_score_gemma":0.00005459296,"domain_scores_codex":[0.9985328,0.0002164313,0.0003186869,0.0002613516,0.0003900339,0.0002806368],"domain_scores_gemma":[0.9988037,0.0001849763,0.00024758,0.0002701703,0.000438269,0.00005526584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004352652,0.00003222641,0.0005496067,0.00004954923,0.0000760293,5.063959e-8,0.0002183834,0.00002336134,0.9897093,0.00001903558,0.00003495457,0.008852299],"study_design_scores_gemma":[0.0002213692,0.00006305135,0.0005670636,0.0002327515,0.0000123095,0.000002540938,0.0003435413,0.0003406336,0.9945874,0.00009571629,0.003430914,0.0001026797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975399,0.001108229,0.0002419698,0.0003815573,0.00007538706,0.0005492755,0.000004906374,0.00000712182,0.00009165961],"genre_scores_gemma":[0.9988245,0.000149206,0.0005022233,0.000003582679,0.0001198213,0.00009232739,0.000078312,0.00002277267,0.0002073023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00874962,"threshold_uncertainty_score":0.4182919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05614337610814241,"score_gpt":0.3530606297103964,"score_spread":0.296917253602254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}