{"id":"W2315423922","doi":"10.1021/ar300072g","title":"The Cation−π Interaction at Protein–Protein Interaction Interfaces: Developing and Learning from Synthetic Mimics of Proteins That Bind Methylated Lysines","year":2012,"lang":"en","type":"article","venue":"Accounts of Chemical Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Methylation; Demethylase; Chemistry; Epigenetics; Lysine; Methyltransferase; Biochemistry; Computational biology; Biology; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273779,0.0005129877,0.0003909755,0.0002316692,0.0002595222,0.0007338288,0.0006230245,0.000750864,0.001546914],"category_scores_gemma":[0.0004368211,0.000321565,0.000521268,0.0001879063,0.0004936325,0.001124941,0.0007188346,0.001352309,0.001419594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004458718,"about_ca_system_score_gemma":0.0002317799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000378595,"about_ca_topic_score_gemma":0.0004121597,"domain_scores_codex":[0.9998515,0.00002015532,0.00001003839,0.00003887753,0.00005101483,0.00002845082],"domain_scores_gemma":[0.9999151,0.00002661129,0.00001555461,0.000006702719,0.0000134717,0.00002257519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001834857,0.0003322871,0.0007381891,0.002749687,0.00006375819,0.0008913641,0.000520948,0.006507421,0.703292,0.03886322,0.007739642,0.2381181],"study_design_scores_gemma":[0.00008681241,0.001397631,0.0009263859,0.0002489333,0.00006144772,0.001068405,0.0001329519,0.01193961,0.6319565,0.008684707,0.3433707,0.0001259046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3459032,0.3798924,0.1780918,0.006076279,0.003347127,0.0003900191,0.00058633,0.003351838,0.08236108],"genre_scores_gemma":[0.6235336,0.256062,0.08460721,0.002230277,0.0008138931,0.0004219978,0.0007662878,0.0003169586,0.03124774],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001546914,"threshold_uncertainty_score":0.005174935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05614337610814241,"score_gpt":0.3530606297103964,"score_spread":0.296917253602254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}