{"id":"W2315450747","doi":"10.1093/annonc/mdu331.38","title":"A Phase I Open-Labelled, Single-Arm, Dose-Escalation, Study of Dichloroacetate (Dca) in Patients with Advanced Solid Tumours","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Solid tumor; Nuclear medicine; Internal medicine; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214374,0.002050012,0.003298609,0.0008644386,0.0007252016,0.001673058,0.001265345,0.001787477,0.004135242],"category_scores_gemma":[0.001100413,0.0009733411,0.001649823,0.001037413,0.002021271,0.001191845,0.0004977057,0.005432269,0.001125717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0015752,"about_ca_system_score_gemma":0.002839362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003562987,"about_ca_topic_score_gemma":0.005644817,"domain_scores_codex":[0.9994282,0.0002171964,0.00001875693,0.0001220179,0.00004333758,0.0001704481],"domain_scores_gemma":[0.9988681,0.0002002423,0.0001174194,0.0001269713,0.0000589245,0.0006283793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.797935,0.1026589,0.002965279,0.0005295485,0.0007733216,0.0001595149,0.0004218363,0.004165464,0.03643301,0.0003667398,0.002656582,0.05093473],"study_design_scores_gemma":[0.616975,0.3738244,0.003487726,0.00001861122,0.0002357499,0.0001259782,0.00008009507,0.0009849293,0.002388314,0.0002173061,0.001628697,0.00003322983],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918441,0.001096767,0.0007589571,0.0006121084,0.0002024408,0.002519944,0.001004472,0.0000964155,0.001864869],"genre_scores_gemma":[0.9861319,0.001805589,0.002126412,0.001171958,0.000234786,0.002816569,0.00199671,0.00007233681,0.003643816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004135242,"threshold_uncertainty_score":0.01383382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03412354744623893,"score_gpt":0.3525730810988975,"score_spread":0.3184495336526585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}