{"id":"W2315483642","doi":"10.1021/jp311109u","title":"Measurement of Proton Chemical Shifts in Invisible States of Slowly Exchanging Protein Systems by Chemical Exchange Saturation Transfer","year":2012,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Electron Spin Resonance Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Magnetization transfer; Excited state; Magnetization; Chemistry; Chemical physics; Chemical shift; Conformational isomerism; Saturation (graph theory); Relaxation (psychology); Molecule; Nuclear magnetic resonance spectroscopy; Proton; Dipole; Nuclear magnetic resonance; Spectroscopy; Computational chemistry; Magnetic field; Atomic physics; Physical chemistry; Physics; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006226514,0.000161677,0.0003309972,0.00001692148,0.00001739111,0.000004736944,0.0002249245,0.00009158091,0.00000273283],"category_scores_gemma":[0.00008330743,0.0001141537,0.0001196099,0.0001175597,0.000119564,0.00001343518,0.00005224405,0.0002234903,2.408125e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006019298,"about_ca_system_score_gemma":0.0000535597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021755,"about_ca_topic_score_gemma":4.350417e-7,"domain_scores_codex":[0.998662,0.00006554527,0.0004261773,0.0001076856,0.0004571603,0.0002814081],"domain_scores_gemma":[0.9992993,0.00001717337,0.0002317349,0.0001655537,0.0002224921,0.00006373763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003001174,0.0003001635,0.0001631657,0.0005650964,0.00006908642,2.421752e-7,0.0004503274,0.00001782955,0.9977894,0.000005662234,0.0001533276,0.0001855832],"study_design_scores_gemma":[0.0005621794,0.0001592073,0.00008587079,0.0002557024,0.0000335972,0.000005371254,0.0001507363,0.00005351513,0.9982726,0.00001925115,0.0002915051,0.0001104476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932816,0.005910799,0.0002963566,0.00008236157,0.00001431546,0.0003259028,0.000008818402,0.000002191936,0.00007764736],"genre_scores_gemma":[0.9994428,0.0001154008,0.0000261486,0.00000731999,0.0003305901,0.00003790552,0.000007840054,0.0000159489,0.00001604604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006161193,"threshold_uncertainty_score":0.4655052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01009413253515963,"score_gpt":0.2374515294714556,"score_spread":0.227357396936296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}