{"id":"W2315524087","doi":"10.1021/np400143j","title":"Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Induces the Production of Anti-inflammatory Cyclodepsipeptides from <i>Beauveria felina</i>","year":2013,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beef Cattle Research Council; Merck KGaA","keywords":"Histone deacetylase inhibitor; Hydroxamic acid; Chemistry; Depsipeptide; Superoxide; Histone deacetylase; Metabolite; Secondary metabolite; Stereochemistry; IC50; Biochemistry; Elastase; Enzyme; In vitro; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008859228,0.0003719705,0.0008236033,0.0002456691,0.0001634157,0.00005707111,0.0003895892,0.0001980508,0.00007128781],"category_scores_gemma":[0.002907708,0.000206739,0.0002669485,0.0005319641,0.0003270014,0.0007559567,0.000103612,0.001175942,0.00004077549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802224,"about_ca_system_score_gemma":0.000303758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002096916,"about_ca_topic_score_gemma":0.00001713635,"domain_scores_codex":[0.9970367,0.0001942528,0.001196141,0.0004762692,0.0007188277,0.0003777869],"domain_scores_gemma":[0.996201,0.0001247267,0.001313806,0.0006409992,0.001581386,0.0001381019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003959874,0.000195013,0.0003995812,0.000168253,0.0002078126,0.00002916866,0.0003544572,0.000004494207,0.9571008,0.000005299944,0.03555784,0.005581273],"study_design_scores_gemma":[0.0006938212,0.0002591869,0.01938749,0.0005432754,0.0002853856,0.0006028807,0.000228707,0.000006239744,0.9752023,0.0001179455,0.002436891,0.0002358384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629523,0.01187685,5.48657e-7,0.02074455,0.003511829,0.0008391316,0.000006918652,0.00003443865,0.00003349216],"genre_scores_gemma":[0.9930752,0.0005773544,0.00130308,0.00035661,0.003926894,0.000001709746,0.00001179319,0.00004213072,0.0007052071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03312095,"threshold_uncertainty_score":0.8430573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00978893222689942,"score_gpt":0.2312000132830417,"score_spread":0.2214110810561423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}