{"id":"W2315524087","doi":"10.1021/np400143j","title":"Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Induces the Production of Anti-inflammatory Cyclodepsipeptides from <i>Beauveria felina</i>","year":2013,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beef Cattle Research Council; Merck KGaA","keywords":"Histone deacetylase inhibitor; Hydroxamic acid; Chemistry; Depsipeptide; Superoxide; Histone deacetylase; Metabolite; Secondary metabolite; Stereochemistry; IC50; Biochemistry; Elastase; Enzyme; In vitro; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009903602,0.0004036681,0.0003024579,0.0001876644,0.0001004009,0.0001447436,0.000217895,0.0003068082,0.0004916521],"category_scores_gemma":[0.0000860827,0.0001243443,0.0002606855,0.0001307176,0.0001526861,0.0001372286,0.0001189052,0.0003524425,0.0001538781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933595,"about_ca_system_score_gemma":0.0001111373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006270491,"about_ca_topic_score_gemma":0.001033124,"domain_scores_codex":[0.9999027,0.00001469698,0.000007713443,0.00002320828,0.00001918905,0.00003244685],"domain_scores_gemma":[0.9999111,0.0000146272,0.0000342823,0.000008426709,0.000008576691,0.0000229767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008300662,0.000009859361,0.00006194159,0.00001632103,0.000003242352,0.00003209922,0.000004328789,0.00002719693,0.9990716,0.000006538385,0.000008436223,0.0006754632],"study_design_scores_gemma":[0.00001464119,0.0007450218,0.004067227,0.000003535163,0.00001014313,0.000199528,0.00001200196,0.0001750388,0.9939667,0.00001114332,0.000790804,0.000004094698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941667,0.002325141,0.001405242,0.0000489035,0.00001540585,0.00002914552,0.0002284716,0.0000645419,0.00171648],"genre_scores_gemma":[0.9966245,0.0006657821,0.001387572,0.00007684302,0.00001218574,0.00001470831,0.0005220653,0.00001009596,0.0006862949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006270491,"threshold_uncertainty_score":0.001644731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00978893222689942,"score_gpt":0.2312000132830417,"score_spread":0.2214110810561423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}