{"id":"W2315559512","doi":"10.1136/annrheumdis-2014-eular.1827","title":"OP0078 Apremilast, an Oral Phosphodiesterase 4 Inhibitor, is Associated with Long-Term (52-WEEK) Improvement in Measures of Disease Activity in Patients with Psoriatic Arthritis: Results from 3 Phase 3, Randomized, Controlled Trials","year":2014,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Medicine; Apremilast; Psoriatic arthritis; Randomized controlled trial; Internal medicine; Placebo; Clinical endpoint; Gastroenterology; Psoriasis; Surgery; Rheumatoid arthritis; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002679478,0.001258659,0.003285807,0.0005782513,0.000432893,0.0009056553,0.0006950088,0.001544405,0.003731896],"category_scores_gemma":[0.002017209,0.0005291687,0.002807554,0.0006298294,0.0008830635,0.0009784438,0.0003141931,0.002738448,0.000594321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004804657,"about_ca_system_score_gemma":0.0006403201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009398955,"about_ca_topic_score_gemma":0.002864996,"domain_scores_codex":[0.9992085,0.0003994583,0.00008051575,0.0001104276,0.0001119173,0.00008912758],"domain_scores_gemma":[0.9988858,0.0005002546,0.0003196544,0.00005044203,0.00006352035,0.0001804002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8932796,0.003791281,0.00133588,0.006674447,0.00537754,0.00009984381,0.00007362323,0.0004387187,0.004843657,0.0001296401,0.002027375,0.08192842],"study_design_scores_gemma":[0.9378791,0.0503276,0.006900761,0.0002284615,0.002365386,0.0001190469,0.00003696054,0.0004066887,0.0006054472,0.0001344404,0.0009649015,0.00003122829],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9082138,0.07830467,0.001438049,0.001823093,0.0009472183,0.002353128,0.002048504,0.0004735904,0.004397909],"genre_scores_gemma":[0.9623367,0.02610612,0.002605213,0.002387799,0.0008109372,0.001738963,0.001803723,0.00004605792,0.002164582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003731896,"threshold_uncertainty_score":0.01417065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04021957772337374,"score_gpt":0.3114789602206468,"score_spread":0.271259382497273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}