{"id":"W2315561570","doi":"10.1021/ol4016354","title":"Povarov-Reductive Amination Cascade to Access 6-Aminoquinolines and Anthrazolines","year":2013,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acadia University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Tandem; Reductive amination; Cascade; Imine; Combinatorial chemistry; Amination; Cascade reaction; Reduction (mathematics); Aminoquinolines; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00003059712,0.0001677703,0.0001694163,0.00004292225,0.00007119044,0.0001378027,0.0002301715,0.00007641142,0.0020785],"category_scores_gemma":[0.0001153177,0.000146785,0.0000356883,0.0001386702,0.00006683882,0.000272192,0.0001410184,0.0001057451,0.0001233342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006320685,"about_ca_system_score_gemma":0.000009503154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001650231,"about_ca_topic_score_gemma":0.000006882332,"domain_scores_codex":[0.9990891,0.00000687272,0.0001786532,0.0003260104,0.0001459421,0.0002534421],"domain_scores_gemma":[0.9994937,0.00006903231,0.00005537065,0.0002014281,0.00004820934,0.0001322982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003642493,0.00002630037,0.001212744,0.0000328649,0.00001826435,0.000002266875,0.0001689889,5.556574e-7,0.9822764,0.00001015104,0.006808068,0.009439695],"study_design_scores_gemma":[0.0001763965,0.000004689563,0.007785176,0.00003230353,0.00001708445,0.0000144791,0.0001266945,0.00002981767,0.9902176,0.00005937076,0.001319493,0.0002168873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824393,0.0000689751,0.00007169713,0.01686171,0.00007281147,0.00008298124,0.000007621649,0.00007468817,0.0003202023],"genre_scores_gemma":[0.9967897,0.00002568441,0.0001818505,0.002215345,0.0004986607,0.00002886238,0.0000112333,0.0000297179,0.0002189736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01464637,"threshold_uncertainty_score":0.9988337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01091165566665502,"score_gpt":0.2424954565331338,"score_spread":0.2315838008664788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}