{"id":"W2315575379","doi":"10.1021/tx4001144","title":"Bioactivation of Sitaxentan in Liver Microsomes, Hepatocytes, and Expressed Human P450s with Characterization of the Glutathione Conjugate by Liquid Chromatography Tandem Mass Spectrometry","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Glutathione; Metabolite; Microsome; Chemistry; Quinone; Conjugate; Stereochemistry; Biochemistry; In vitro; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598805,0.0003161104,0.0001595222,0.0001589557,0.0001569008,0.0001565969,0.0001847123,0.0002290035,0.000545755],"category_scores_gemma":[0.0001670829,0.0001379716,0.0002651163,0.0002061603,0.0001890129,0.0001346776,0.000102099,0.0003425771,0.0002650834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002866469,"about_ca_system_score_gemma":0.0001781902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001710609,"about_ca_topic_score_gemma":0.001878163,"domain_scores_codex":[0.9998657,0.0000376547,0.000008216229,0.00002904955,0.0000428746,0.00001647257],"domain_scores_gemma":[0.9999572,0.000010797,0.00001212297,0.000006357141,0.000009033803,0.000004384011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014548,0.00003162486,0.000477832,0.00002806321,0.00001924914,0.00007600442,0.00002960641,0.0007221467,0.9970835,0.0001504981,0.00004459955,0.00123547],"study_design_scores_gemma":[0.0000132682,0.0002711013,0.002357523,0.000002002519,0.00001532694,0.0001856006,0.00002489734,0.004172021,0.992262,0.00007009153,0.0006199957,0.000006079082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854568,0.000979088,0.01200346,0.0001081807,0.00001390766,0.00003416616,0.0005100514,0.00009115948,0.0008032977],"genre_scores_gemma":[0.9932792,0.0007070205,0.004140959,0.00003419219,0.000008401121,0.00003389034,0.0007590747,0.00001524286,0.001021999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001710609,"threshold_uncertainty_score":0.003401279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02138145538696335,"score_gpt":0.2929208288141067,"score_spread":0.2715393734271433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}