{"id":"W2315579748","doi":"10.1042/bj20151153","title":"Contributions of a unique β-clamp to substrate recognition illuminates the molecular basis of exolysis in ferulic acid esterases","year":2016,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"","keywords":"Ferulic acid; Substrate specificity; Substrate (aquarium); Chemistry; Biochemistry; Basis (linear algebra); Computational biology; Biology; Enzyme; Ecology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000267652,0.00009244998,0.0001413803,0.00006988427,0.00002120928,0.000006978878,0.0001286382,0.00009808566,0.00001373238],"category_scores_gemma":[0.0004225099,0.00005640603,0.00009836777,0.0001722496,0.00007536403,0.000003895212,0.00003182454,0.00007473179,0.00000169012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001605217,"about_ca_system_score_gemma":0.00003900017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008906257,"about_ca_topic_score_gemma":0.000002707453,"domain_scores_codex":[0.9992774,0.00006319468,0.0002886914,0.0001422403,0.00008287744,0.0001455667],"domain_scores_gemma":[0.9994585,0.000009622988,0.0001047168,0.0001572701,0.0002082484,0.00006165241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007135166,0.00004972637,0.0001543617,0.000009121859,0.00003211513,0.00000127409,0.00001743686,0.000005725905,0.9956236,0.00001510352,0.0002118004,0.003808336],"study_design_scores_gemma":[0.0003143665,0.00009424495,0.0009057588,0.00009566332,0.0000229233,0.00006038558,0.00002511203,9.871062e-7,0.9977347,0.00007809755,0.0005842834,0.00008344126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938827,0.000825286,0.00401154,0.001053287,0.00006714001,0.00008763403,0.0000583386,0.00000309203,0.0000110045],"genre_scores_gemma":[0.9988086,0.0003618849,0.000617008,0.00004290442,0.0001190934,0.000007290424,0.00001567711,0.00000752276,0.00002002126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004925919,"threshold_uncertainty_score":0.2300171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006668994061996783,"score_gpt":0.2287284407873877,"score_spread":0.2220594467253909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}