{"id":"W2315581089","doi":"10.1021/sb3000172","title":"Engineered Networks of Synthetic and Natural Proteins To Control Cell Migration","year":2012,"lang":"en","type":"letter","venue":"ACS Synthetic Biology","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CDC42; Cell biology; Cell migration; Lamellipodium; RAC1; Biology; Chimera (genetics); Synthetic biology; Cell; Filopodia; Signal transduction; Computational biology; Actin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004335752,0.0003488642,0.000580692,0.0002760736,0.00003189508,0.00001820936,0.0004032869,0.001238179,0.00007651431],"category_scores_gemma":[0.0003449925,0.0002984127,0.00008129612,0.000173208,0.0002438665,0.00002682332,0.0001103596,0.001601454,0.00005245614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006114806,"about_ca_system_score_gemma":0.00002405051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000367943,"about_ca_topic_score_gemma":0.000004922671,"domain_scores_codex":[0.9980577,0.00017905,0.0004246852,0.0003540833,0.0002048212,0.0007796817],"domain_scores_gemma":[0.9983805,0.0008596217,0.00007355124,0.0004762563,0.00007612082,0.000133954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001306765,0.0001735323,0.0007987557,0.005243706,0.001072589,0.00009161754,0.0008130092,0.0034735,0.537927,0.0004552978,0.3335914,0.1162289],"study_design_scores_gemma":[0.001084043,0.0005086497,0.00116952,0.000721565,0.000287098,0.00008197961,0.0000172282,0.04825369,0.03640933,0.0003912961,0.9094257,0.001649852],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2307859,0.03042944,0.1704687,0.5443264,0.010553,0.00858994,0.0005317628,0.001570772,0.002744126],"genre_scores_gemma":[0.9895179,0.0001644858,0.0008220864,0.007926139,0.001079791,0.0001606979,0.00007389092,0.00008546647,0.0001695969],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7587319,"threshold_uncertainty_score":0.9999468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007874007919275443,"score_gpt":0.2247145118695516,"score_spread":0.2168405039502761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}