{"id":"W2315581089","doi":"10.1021/sb3000172","title":"Engineered Networks of Synthetic and Natural Proteins To Control Cell Migration","year":2012,"lang":"en","type":"letter","venue":"ACS Synthetic Biology","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CDC42; Cell biology; Cell migration; Lamellipodium; RAC1; Biology; Chimera (genetics); Synthetic biology; Cell; Filopodia; Signal transduction; Computational biology; Actin; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268951,0.0004482366,0.0002227961,0.0002236828,0.0001531906,0.0002914817,0.0004742779,0.0004209872,0.0009643353],"category_scores_gemma":[0.0002237671,0.0002244988,0.0002374238,0.000206224,0.0003201078,0.0003930732,0.0002434361,0.0005233206,0.0004424749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006667303,"about_ca_system_score_gemma":0.000270224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003774684,"about_ca_topic_score_gemma":0.0007802909,"domain_scores_codex":[0.9998149,0.00002333963,0.00001420082,0.00005994939,0.00005765419,0.00002998377],"domain_scores_gemma":[0.9998568,0.00001827881,0.00005745561,0.0000131226,0.00001883721,0.00003547558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003458959,0.00002749508,0.0000728936,0.00007466535,0.000007449157,0.00002858128,0.0000142635,0.0008521589,0.9944343,0.001484926,0.0001333734,0.00283532],"study_design_scores_gemma":[0.00002645675,0.0001636359,0.0004489435,0.00001003154,0.00001771734,0.000118856,0.00001267235,0.005714768,0.9737703,0.0002635721,0.01944204,0.00001107911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8233132,0.004638573,0.1596408,0.0005724324,0.0002930656,0.0002957199,0.0007893237,0.001117786,0.009339098],"genre_scores_gemma":[0.8946856,0.002995132,0.09321535,0.0002331774,0.00003414607,0.0004054153,0.0007389571,0.0001925994,0.007499626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009643353,"threshold_uncertainty_score":0.004837513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007874007919275443,"score_gpt":0.2247145118695516,"score_spread":0.2168405039502761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}