{"id":"W2315606499","doi":"10.1515/hc.2003.9.6.551","title":"Synthesis and in Vitro Anticancer Evaluation of (S)-2-Amino-3-(3-indolyl)propionic acid (L-Tryptophan) Pyrrole & Imidazole Polyamide Conjugates","year":2003,"lang":"en","type":"article","venue":"Heterocyclic Communications","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Imidazole; Pyrrole; Conjugate; Tryptophan; In vitro; Polyamide; Amino acid; Combinatorial chemistry; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002741534,0.0005200999,0.0002672756,0.0002095132,0.0001555064,0.0001864955,0.0001957491,0.000237774,0.00134832],"category_scores_gemma":[0.0001797446,0.00016776,0.0001744986,0.0001830783,0.0001437564,0.0001915562,0.00009789028,0.0003218695,0.0004002237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684099,"about_ca_system_score_gemma":0.0002866354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004167304,"about_ca_topic_score_gemma":0.0007497608,"domain_scores_codex":[0.9998367,0.0000454836,0.00001801089,0.00002849319,0.00004512353,0.00002614011],"domain_scores_gemma":[0.9997966,0.00005469296,0.00005113731,0.00002359077,0.000031753,0.00004229659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006716756,0.0000355774,0.00002061679,0.0000210588,0.000001586679,0.00002474114,0.000007563287,0.0001040839,0.9986117,0.00003010045,0.00001928077,0.001056545],"study_design_scores_gemma":[0.00001616713,0.0007278544,0.0002523256,0.000001479985,0.000007508863,0.00005854144,0.000002721001,0.0002582558,0.9980075,0.00000568671,0.0006601791,0.000001743381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807326,0.002407087,0.01081087,0.00008021347,0.00008879058,0.0002885993,0.0004534181,0.0001332255,0.005005268],"genre_scores_gemma":[0.9757774,0.001578517,0.01575978,0.00003397507,0.00003525928,0.000235599,0.000846516,0.00003499006,0.005697945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00134832,"threshold_uncertainty_score":0.004510581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0661989264811101,"score_gpt":0.3733933584663466,"score_spread":0.3071944319852365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}