{"id":"W2315606499","doi":"10.1515/hc.2003.9.6.551","title":"Synthesis and in Vitro Anticancer Evaluation of (S)-2-Amino-3-(3-indolyl)propionic acid (L-Tryptophan) Pyrrole & Imidazole Polyamide Conjugates","year":2003,"lang":"en","type":"article","venue":"Heterocyclic Communications","topic":"Neuroendocrine Tumor Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Imidazole; Pyrrole; Conjugate; Tryptophan; In vitro; Polyamide; Amino acid; Combinatorial chemistry; Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004946478,0.0001812491,0.000409148,0.0003056389,0.0001364115,0.00002248449,0.0003334125,0.0000237224,0.0001763706],"category_scores_gemma":[0.002161012,0.0001744728,0.00007664589,0.0003714834,0.0004146546,0.0001807756,0.0001991193,0.0003345458,0.00003039876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371758,"about_ca_system_score_gemma":0.0001393922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001238822,"about_ca_topic_score_gemma":0.0005105586,"domain_scores_codex":[0.9976695,0.000623981,0.0005042247,0.0003006594,0.0005410607,0.0003606285],"domain_scores_gemma":[0.9971018,0.0006891065,0.0001599651,0.001674164,0.0002260416,0.0001489478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002334863,0.0005684606,0.01851257,0.0001356401,0.00006539631,0.000008884665,0.0002008924,0.00002024556,0.9682049,0.0003230807,0.000034097,0.01169235],"study_design_scores_gemma":[0.001857654,0.00006688151,0.03120432,0.0002513804,0.0001566883,0.0002335154,0.0003155034,0.001255937,0.9608669,0.0007787859,0.002813796,0.00019859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876339,0.006985692,0.00002468627,0.001605224,0.00003271225,0.0008426119,0.00002037906,0.00004145432,0.002813325],"genre_scores_gemma":[0.9942627,0.002318778,0.002761984,0.0001086908,0.0000111226,0.0004134024,0.00002362422,0.00002965638,0.00007006444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01269175,"threshold_uncertainty_score":0.7114794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0661989264811101,"score_gpt":0.3733933584663466,"score_spread":0.3071944319852365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}