{"id":"W2315607170","doi":"10.1158/1538-7445.am2011-2530","title":"Abstract 2530: The anticancer kinase inhibitor dovitinib (TKI258/CHIR258) may have multiple modes of action because it also binds DNA and inhibits topoisomerase I and topoisomerase IIα","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Topoisomerase; Tyrosine kinase; Biology; Biochemistry; Kinase; Molecular biology; Tyrosine-kinase inhibitor; Fibroblast growth factor receptor; DNA; Receptor; Fibroblast growth factor; Chemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007550467,0.0004936636,0.0002614701,0.0002762105,0.0002704075,0.0004320576,0.0002990179,0.0005410534,0.01959739],"category_scores_gemma":[0.00008554205,0.0001169484,0.0002204737,0.0001947739,0.0001554635,0.0002004155,0.0001728987,0.0005700731,0.003984826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005003568,"about_ca_system_score_gemma":0.000308641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036687,"about_ca_topic_score_gemma":0.001413343,"domain_scores_codex":[0.9999247,0.000005848111,0.000005059145,0.00001693899,0.00003308905,0.00001440319],"domain_scores_gemma":[0.9999592,0.000004639284,0.0000108849,0.000002170024,0.00001048868,0.00001264574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001494625,0.0003951623,0.001362469,0.0006293294,0.00004439133,0.000598522,0.00002186335,0.0002804225,0.9141556,0.001827776,0.01247118,0.06671878],"study_design_scores_gemma":[0.0004537155,0.002135518,0.01697065,0.0001210063,0.0001269877,0.003399309,0.00004865534,0.00132146,0.811647,0.0006236091,0.1631242,0.00002788568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7229657,0.06733669,0.01021868,0.006178618,0.004077575,0.0004247332,0.006668743,0.001310714,0.1808186],"genre_scores_gemma":[0.8377489,0.01255866,0.003713606,0.001165117,0.0004324731,0.0001114347,0.006339688,0.00006141312,0.1378688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01959739,"threshold_uncertainty_score":0.06555974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1557381596321504,"score_gpt":0.4410244729244736,"score_spread":0.2852863132923231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}