{"id":"W2315651413","doi":"10.1242/dev.132738","title":"LEP-2/Makorin regulates LIN-28 stability to promote the juvenile-to-adult transition in <i>Caenorhabditis elegans</i>","year":2016,"lang":"en","type":"article","venue":"Development","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; New York University Shanghai","keywords":"Biology; Heterochrony; Caenorhabditis elegans; Juvenile; Mutant; Caenorhabditis; Gene; Genetics; Mutation; Vertebrate; Developmental biology; Moulting; Cell biology; Evolutionary biology; Ecology; Larva","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004290473,0.0002170343,0.0001778946,0.00005245386,0.000110698,0.00003138567,0.0003018292,0.0001240751,0.00003750739],"category_scores_gemma":[0.00008094658,0.0001502582,0.00005173177,0.0001375586,0.00005050419,0.000005471544,0.0001174871,0.00007691348,0.00007614287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008727148,"about_ca_system_score_gemma":0.0001641697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004123354,"about_ca_topic_score_gemma":0.0009304874,"domain_scores_codex":[0.9983956,0.00006881603,0.000379701,0.0005254716,0.0002257841,0.0004045931],"domain_scores_gemma":[0.9991924,0.00001184497,0.00004895246,0.0004594419,0.0001398916,0.0001474377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009572286,0.000143995,0.002000607,0.00003095677,0.00003414135,0.000005397039,0.007156808,0.0001238866,0.9477624,0.00004163182,0.001490423,0.04111407],"study_design_scores_gemma":[0.0004476914,0.000155087,0.02928186,0.00005235022,0.000006520497,0.000006006783,0.0001096533,0.000007194671,0.8777491,0.0001306313,0.09176483,0.000289087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782379,0.00005804169,0.01494626,0.005780979,0.0002081738,0.0005985055,0.00002634485,0.00002174672,0.0001220777],"genre_scores_gemma":[0.9901407,0.00004326808,0.007495136,0.001546413,0.0001338658,0.0001173872,0.00003540349,0.00002978007,0.0004580673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09027441,"threshold_uncertainty_score":0.612735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008622528907661704,"score_gpt":0.2095161298535064,"score_spread":0.2008936009458447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}