{"id":"W2315792699","doi":"10.1016/j.biopsych.2016.02.009","title":"Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment","year":2016,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital","funders":"National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Glutamatergic; AMPA receptor; GABAergic; Glutamate receptor; Neuroscience; NMDA receptor; Prefrontal cortex; Hippocampus; Neurotransmission; gamma-Aminobutyric acid; GABAA receptor; Biology; Receptor; Inhibitory postsynaptic potential; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001100784,0.0004015327,0.0003122209,0.0001870558,0.00009953592,0.0002358231,0.000297519,0.0002477657,0.0006159581],"category_scores_gemma":[0.0001370136,0.0001248388,0.0002045447,0.0001019073,0.0003100939,0.0002067225,0.0002301341,0.0006833135,0.000148778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758534,"about_ca_system_score_gemma":0.0002106098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004576299,"about_ca_topic_score_gemma":0.00126055,"domain_scores_codex":[0.9998851,0.00002014562,0.0000131587,0.00002276602,0.00002421758,0.00003468902],"domain_scores_gemma":[0.9999108,0.000005475367,0.00004407058,0.00001191393,0.000007383662,0.00002033535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001979224,0.0002494593,0.0008911401,0.00005241598,0.00002786254,0.0001186342,0.0000227104,0.00007802335,0.9914002,0.0001432682,0.00008802705,0.004948973],"study_design_scores_gemma":[0.0008166541,0.01176694,0.07938146,0.00008112642,0.0002509863,0.001499557,0.0002318618,0.002145406,0.9001674,0.0003891137,0.003238507,0.00003106643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971328,0.0007823494,0.0008000778,0.00007069791,0.00002374739,0.0000674428,0.000192378,0.00004526259,0.0008852453],"genre_scores_gemma":[0.9975628,0.0006282174,0.0007803097,0.00006449993,0.0000123991,0.0001100874,0.0002395005,0.00001031026,0.000591864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006159581,"threshold_uncertainty_score":0.002060592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650888919769694,"score_gpt":0.2615853520120085,"score_spread":0.2450764628143116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}