{"id":"W2315909892","doi":"10.1097/tp.0000000000000237","title":"Serine Protease Inhibitor-6 Inhibits Granzyme B–Mediated Injury of Renal Tubular Cells and Promotes Renal Allograft Survival","year":2014,"lang":"en","type":"article","venue":"Transplantation","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Granzyme B; Serine protease; Granzyme; Renal injury; Medicine; Proteases; Serine; Chemistry; Cancer research; Kidney; Protease; Immunology; Internal medicine; Perforin; Immune system; Biochemistry; CD8; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003188703,0.0001917364,0.0001929841,0.00006630838,0.00005871289,0.0000148202,0.00008432463,0.0001760468,0.00001097677],"category_scores_gemma":[0.00002595525,0.0001802882,0.00006092769,0.00009271855,0.00007639838,0.00001469297,0.00002167983,0.00009988715,0.000003722547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004530542,"about_ca_system_score_gemma":0.00003922736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003526421,"about_ca_topic_score_gemma":0.00002536657,"domain_scores_codex":[0.9988073,0.0001403573,0.0003098129,0.0003347681,0.0001981721,0.0002096276],"domain_scores_gemma":[0.9994933,0.00001443956,0.0001176429,0.0001798695,0.00008621264,0.0001085601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004651319,0.00008989697,0.0001408652,0.0001663119,0.00002826148,0.000003923687,0.0000812998,0.00001015814,0.9984138,0.00009073455,0.00006962305,0.0004400175],"study_design_scores_gemma":[0.001271391,0.001060302,0.0001960691,0.0000913066,0.00004879737,0.00001467747,0.000007572988,0.0001447148,0.9960181,0.000173192,0.000763995,0.0002099531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918411,0.00009927272,0.007151907,0.00004940206,0.00009523363,0.0004844901,0.0001640171,0.00002602929,0.00008858155],"genre_scores_gemma":[0.9977418,0.0001828651,0.000978488,0.00005371797,0.0002128764,0.00004343261,0.0007124075,0.00002455139,0.00004984951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006173419,"threshold_uncertainty_score":0.7351938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005615720000125685,"score_gpt":0.2107558277324042,"score_spread":0.2051401077322785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}