{"id":"W2315998190","doi":"10.1021/jm101540e","title":"Structure−Activity Relationships of an Antimicrobial Peptide Plantaricin S from Two-Peptide Class IIb Bacteriocins","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"CanBiocin (Canada); University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Bacteriocin; Peptide; Antimicrobial; Antibacterial agent; Stereochemistry; Structure–activity relationship; Biological activity; Cyclic peptide; Biochemistry; Combinatorial chemistry; Microbiology; Antibiotics; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009841141,0.000174757,0.0001219053,0.0001674444,0.00007275096,0.0002035129,0.0001043395,0.0001675273,0.0003505375],"category_scores_gemma":[0.0002025381,0.00009069812,0.000171128,0.0001148882,0.0001365484,0.0001001225,0.00008268043,0.0002202094,0.00007030219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000227266,"about_ca_system_score_gemma":0.0001298135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005149328,"about_ca_topic_score_gemma":0.0003971362,"domain_scores_codex":[0.9999355,0.00001303214,0.000004323625,0.000008164087,0.00002412967,0.00001488135],"domain_scores_gemma":[0.9999372,0.00001632435,0.00001972216,0.000002537242,0.00001025473,0.00001398152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002365445,0.00004726361,0.001423487,0.00003450478,0.00000935679,0.00008308102,0.00001597486,0.004866699,0.9913823,0.0001236548,0.00002419246,0.001752947],"study_design_scores_gemma":[0.00007264937,0.001408744,0.01118719,0.000008306045,0.00003148811,0.0002926569,0.00004874891,0.03718739,0.9487166,0.0001457846,0.0008858291,0.00001470468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998872,0.0002629572,0.0004913195,0.00001459905,0.000001921093,0.000003662404,0.00003696365,0.000005019867,0.0003114898],"genre_scores_gemma":[0.9987528,0.0001723096,0.0007436259,0.00001300095,9.336328e-7,0.00000428849,0.0001367911,0.00000136004,0.0001747433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005149328,"threshold_uncertainty_score":0.001648962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400060239470892,"score_gpt":0.2302489033352043,"score_spread":0.2062483009404953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}