{"id":"W2315998190","doi":"10.1021/jm101540e","title":"Structure−Activity Relationships of an Antimicrobial Peptide Plantaricin S from Two-Peptide Class IIb Bacteriocins","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"CanBiocin (Canada); University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Bacteriocin; Peptide; Antimicrobial; Antibacterial agent; Stereochemistry; Structure–activity relationship; Biological activity; Cyclic peptide; Biochemistry; Combinatorial chemistry; Microbiology; Antibiotics; In vitro; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003935221,0.0002797156,0.0006927175,0.00008972341,0.0001614829,0.00001221627,0.0004232543,0.0003484553,0.00197247],"category_scores_gemma":[0.0001422295,0.0002314342,0.0002062851,0.00009991555,0.0004809115,0.0003576086,0.00006964544,0.001344177,0.00001083039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007984035,"about_ca_system_score_gemma":0.0002372119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135258,"about_ca_topic_score_gemma":0.0001343391,"domain_scores_codex":[0.9983924,0.0001844187,0.0007353885,0.0002428325,0.0001188,0.0003261602],"domain_scores_gemma":[0.9981054,0.000214239,0.001108328,0.000291395,0.0001885716,0.00009204257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001568741,0.0001949345,0.006940451,0.00005576446,0.000299463,0.00006878311,0.001278482,0.0000105226,0.9864428,0.00001160727,0.002356174,0.0007722729],"study_design_scores_gemma":[0.002201329,0.0003110528,0.0262494,0.0003234009,0.0002611245,0.001220545,0.001176608,0.000004458028,0.9668963,0.0001843461,0.0009404703,0.000230976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970473,0.0002296157,0.0001705888,0.0001071182,0.0005356853,0.00006606351,0.0002968199,0.00001618389,0.001530623],"genre_scores_gemma":[0.9977611,0.00005624572,0.00108433,0.00008266567,0.0004312092,3.569601e-7,0.0001119459,0.00002398064,0.000448151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01954651,"threshold_uncertainty_score":0.9989399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400060239470892,"score_gpt":0.2302489033352043,"score_spread":0.2062483009404953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}