{"id":"W2316178266","doi":"10.1021/ac202404y","title":"Liquid Chromatography–Coupled Tandem Mass Spectrometry Based Assay to Evaluate Inosine-5′-monophosphate Dehydrogenase Activity in Peripheral Blood Mononuclear Cells from Stem Cell Transplant Recipients","year":2011,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; IMP dehydrogenase; Inosine monophosphate; Inosine; Mycophenolic acid; Therapeutic drug monitoring; Peripheral blood mononuclear cell; Chromatography; Pharmacology; Transplantation; Mycophenolate; Selected reaction monitoring; Tandem mass spectrometry; Liquid chromatography–mass spectrometry; Analyte; Pharmacokinetics; Biochemistry; Mass spectrometry; Enzyme; In vitro; Medicine; Internal medicine; Nucleotide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001793578,0.001476675,0.000789586,0.002038115,0.0005458658,0.0008724399,0.000830834,0.001758831,0.001287527],"category_scores_gemma":[0.002410951,0.0005372129,0.0006691986,0.001266466,0.0005677322,0.000536086,0.0005702638,0.001516596,0.001621654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005551684,"about_ca_system_score_gemma":0.001120165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008067852,"about_ca_topic_score_gemma":0.001736879,"domain_scores_codex":[0.9963655,0.0006647084,0.0002596416,0.0009610634,0.00159904,0.000149916],"domain_scores_gemma":[0.9986876,0.0004285875,0.0002954797,0.0001076031,0.0004032884,0.00007750669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002474954,0.000298909,0.006013664,0.0002641757,0.000127199,0.0001456348,0.00006469936,0.0002757589,0.9724112,0.0001671499,0.0006132764,0.01937093],"study_design_scores_gemma":[0.00004610791,0.0008071447,0.01733735,0.00007038332,0.0001683077,0.001298951,0.00005349877,0.006936323,0.966735,0.0002643283,0.006224284,0.00005832534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4796157,0.0282898,0.459545,0.00145579,0.001175047,0.002495553,0.009009091,0.006737267,0.01167678],"genre_scores_gemma":[0.5989925,0.01039474,0.36419,0.004294008,0.0005048437,0.003391985,0.006807433,0.0003738122,0.01105057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002038115,"threshold_uncertainty_score":0.009485483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135012619419858,"score_gpt":0.2560652600711221,"score_spread":0.2347151338769236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}