{"id":"W2316195621","doi":"10.1089/hum.2014.2530","title":"Retinal Gene Therapy Using Adeno-Associated Viral Vectors: Multiple Applications for a Small Virus","year":2014,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Eye Institute; Canadian Institutes of Health Research; University of Florida; Macula Vision Research Foundation; Research to Prevent Blindness; National Institutes of Health; Foundation Fighting Blindness","keywords":"Adeno-associated virus; Transduction (biophysics); Genetic enhancement; Retinal; Viral vector; Gene delivery; Biology; Virology; Gene; Hum; Virus; Capsid; Vector (molecular biology); Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002537488,0.0002351128,0.0001946589,0.00005283826,0.0003368388,0.00004628897,0.0002641517,0.0001663843,0.00002935293],"category_scores_gemma":[0.00002214694,0.0002255267,0.0001564428,0.00008028485,0.00007044038,0.000004000174,0.00003369644,0.00006682221,0.000006544332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002604122,"about_ca_system_score_gemma":0.00005576393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005551152,"about_ca_topic_score_gemma":0.0000705842,"domain_scores_codex":[0.9987884,0.00008363147,0.0002528864,0.0004185358,0.0001131388,0.0003433979],"domain_scores_gemma":[0.9993163,0.00002071614,0.0001460696,0.0003267708,0.0001158777,0.00007431554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000281071,0.0001521618,0.003182088,0.000004283784,0.00009566882,2.342354e-7,0.0001061085,0.00003515548,0.9920194,0.00005380055,0.000264827,0.003805262],"study_design_scores_gemma":[0.004034098,0.0008784627,0.0100576,0.000007575037,0.00001517589,0.00000434718,0.00002922318,0.0003129035,0.909261,0.0008638772,0.0740254,0.0005103133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814718,0.001315451,0.01607373,0.0000377528,0.00006414043,0.0007651285,0.00002270939,0.0000392868,0.0002100454],"genre_scores_gemma":[0.9930038,0.0006197341,0.003979082,0.0005174055,0.0004443307,0.0002865535,0.0007186872,0.00006479141,0.0003655886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08275831,"threshold_uncertainty_score":0.9196712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03652048504150172,"score_gpt":0.2794218730499364,"score_spread":0.2429013880084347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}