{"id":"W2316195621","doi":"10.1089/hum.2014.2530","title":"Retinal Gene Therapy Using Adeno-Associated Viral Vectors: Multiple Applications for a Small Virus","year":2014,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Eye Institute; Canadian Institutes of Health Research; University of Florida; Macula Vision Research Foundation; Research to Prevent Blindness; National Institutes of Health; Foundation Fighting Blindness","keywords":"Adeno-associated virus; Transduction (biophysics); Genetic enhancement; Retinal; Viral vector; Gene delivery; Biology; Virology; Gene; Hum; Virus; Capsid; Vector (molecular biology); Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009569907,0.0009034266,0.0008525638,0.001271265,0.0007039698,0.002043964,0.0006926017,0.001126496,0.001368162],"category_scores_gemma":[0.0003456998,0.0003569711,0.001069052,0.0007152059,0.001089823,0.001471185,0.0008523015,0.001863468,0.0004479783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001103359,"about_ca_system_score_gemma":0.001019558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161193,"about_ca_topic_score_gemma":0.001975194,"domain_scores_codex":[0.9996253,0.00004365873,0.00002933992,0.0000979442,0.0001455249,0.00005819518],"domain_scores_gemma":[0.9997578,0.00008340622,0.00003095286,0.00003423445,0.00003501556,0.00005846988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002915403,0.00009766337,0.0003580457,0.0002397356,0.00003110342,0.0002311411,0.0001150385,0.0003981256,0.934971,0.005196216,0.0003313492,0.05773904],"study_design_scores_gemma":[0.00004499058,0.0007265669,0.001000709,0.00008208304,0.0001704257,0.001169929,0.0001031528,0.001243159,0.9593846,0.002563976,0.03345864,0.00005196956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4495108,0.2229774,0.2881861,0.006231748,0.001248739,0.0005990802,0.0004022479,0.00115526,0.0296885],"genre_scores_gemma":[0.7026452,0.1169172,0.1549857,0.0008194504,0.0003262234,0.0002708583,0.0004046321,0.0002568953,0.02337392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002043964,"threshold_uncertainty_score":0.00800544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03652048504150172,"score_gpt":0.2794218730499364,"score_spread":0.2429013880084347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}