{"id":"W2316226082","doi":"10.1158/1538-7445.am2015-ct302","title":"Abstract CT302: Pharmacokinetics (PK) and safety of ARN-509 with abiraterone acetate (AA) and prednisone (P) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC)","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; BC Cancer Agency","funders":"","keywords":"Prostate cancer; Abiraterone acetate; Medicine; Enzalutamide; Docetaxel; Internal medicine; Androgen receptor; Pharmacokinetics; Prednisone; Pharmacology; Gastroenterology; Urology; Cancer; Androgen deprivation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004017276,0.000495707,0.0006782119,0.0003107998,0.0002379958,0.0006043231,0.0003570338,0.000416935,0.002926419],"category_scores_gemma":[0.0009589955,0.000255555,0.0003980818,0.0004032135,0.0004188236,0.0004502769,0.0001644943,0.001152176,0.0007101122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007467702,"about_ca_system_score_gemma":0.001233666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00241302,"about_ca_topic_score_gemma":0.003193907,"domain_scores_codex":[0.9996846,0.0001339924,0.00001971009,0.00004502846,0.00007412279,0.00004263241],"domain_scores_gemma":[0.9996093,0.00007540208,0.00009011453,0.00002762135,0.00002174286,0.0001759376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.4589495,0.01505973,0.03123809,0.0005586224,0.0008343923,0.001058519,0.0004233833,0.009453454,0.2863153,0.0004330393,0.006028113,0.1896479],"study_design_scores_gemma":[0.07956968,0.57339,0.2052186,0.0001357814,0.001164947,0.004080806,0.0002454953,0.01826026,0.1027258,0.0004865668,0.01459275,0.0001292927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.995456,0.001196557,0.0004545685,0.000104757,0.0000158487,0.0002156553,0.0006166709,0.0001135896,0.001826298],"genre_scores_gemma":[0.9971753,0.0003205182,0.0004530782,0.00007681316,0.00002313332,0.0001023737,0.0007828097,0.00001555757,0.001050248],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002926419,"threshold_uncertainty_score":0.009789824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08136193661629539,"score_gpt":0.3951573112347669,"score_spread":0.3137953746184716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}