{"id":"W2316247839","doi":"10.1139/cjpp-2012-0257","title":"Triton X-100 inhibits L-type voltage-operated calcium channels","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Depolarization; Biophysics; Membrane potential; Patch clamp; Calcium; Voltage-dependent calcium channel; Exocytosis; Electrophysiology; Potassium channel; L-type calcium channel; Endocrinology; Internal medicine; Biochemistry; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002086981,0.000763793,0.000546315,0.0003641946,0.0001320605,0.0004695936,0.0003121128,0.0005001241,0.0009098216],"category_scores_gemma":[0.0003007468,0.0001609974,0.0004350352,0.0002857641,0.0002574234,0.0003117028,0.0003288829,0.0008865403,0.0005973541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488889,"about_ca_system_score_gemma":0.0003032665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003791956,"about_ca_topic_score_gemma":0.0004897159,"domain_scores_codex":[0.9996504,0.00004695052,0.0000668137,0.00007430058,0.00009810043,0.00006348245],"domain_scores_gemma":[0.9997953,0.00006557078,0.00005977079,0.00002687593,0.0000290689,0.00002352027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005034425,0.00003499371,0.0001181237,0.0001013601,0.00001090504,0.00005699568,0.00001293828,0.00003454952,0.9976332,0.00011088,0.00005738324,0.001778189],"study_design_scores_gemma":[0.0000247482,0.0002623124,0.002133592,0.00002128449,0.00002250883,0.0002608665,0.00001192731,0.0003406708,0.9909142,0.00007516337,0.005928558,0.000004136884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9191676,0.04044262,0.02839867,0.0006478218,0.0003947419,0.000344233,0.001104922,0.0006750284,0.008824352],"genre_scores_gemma":[0.9447148,0.03218877,0.01244861,0.0003749421,0.0001428166,0.0005054506,0.002602894,0.000139124,0.006882653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009098216,"threshold_uncertainty_score":0.003043711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01846060336402174,"score_gpt":0.2664573016947919,"score_spread":0.2479966983307702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}