{"id":"W2316248690","doi":"10.1021/op2001063","title":"Convergent Kilo-Scale Synthesis of a Potent Renin Inhibitor for the Treatment of Hypertension","year":2011,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Blood Pressure and Hypertension Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Reagent; Yield (engineering); Renin inhibitor; Combinatorial chemistry; Sequence (biology); Chemistry; Renin–angiotensin system; Organic chemistry; Medicine; Materials science; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003472455,0.0003874124,0.0003909201,0.0001980954,0.00022081,0.000277124,0.0004399708,0.0002975355,0.002110594],"category_scores_gemma":[0.0003295323,0.0002094389,0.0003234701,0.0001830572,0.0002269429,0.0004392222,0.0003798594,0.0009377067,0.001311362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181285,"about_ca_system_score_gemma":0.0005233006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002533314,"about_ca_topic_score_gemma":0.0007137818,"domain_scores_codex":[0.9998105,0.00003108554,0.00001723376,0.00003010955,0.00008074133,0.00003029897],"domain_scores_gemma":[0.9998841,0.00002589892,0.00002133858,0.00001721049,0.00002081973,0.00003054573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546997,0.0001184218,0.00007302569,0.0002324537,0.0000227931,0.0004015123,0.0000780921,0.00111248,0.980923,0.001476163,0.0003842211,0.01502316],"study_design_scores_gemma":[0.0001132917,0.001074047,0.0007456811,0.00001963144,0.00004611099,0.0008065515,0.00002685166,0.002186225,0.9770883,0.000580763,0.01727982,0.00003265341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6155266,0.01464146,0.326987,0.0008945056,0.0006452518,0.0009363821,0.002084808,0.001097141,0.03718673],"genre_scores_gemma":[0.8414484,0.01117524,0.1308589,0.0002256609,0.0001595312,0.0003152597,0.001118827,0.0002026598,0.01449544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002110594,"threshold_uncertainty_score":0.007060647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1378410604702235,"score_gpt":0.3285809736220887,"score_spread":0.1907399131518652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}