{"id":"W2316261099","doi":"10.1158/1538-7445.am2013-247","title":"Abstract 247: ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Reprogramming; Myeloid leukemia; Biology; Progenitor cell; Cancer research; Small hairpin RNA; Stem cell; Myeloid; Leukemia; Gene knockdown; Immunology; Cell biology; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223928,0.000201663,0.0001704699,0.0001713749,0.0001565284,0.0002758258,0.0001367677,0.0002283194,0.002682986],"category_scores_gemma":[0.00004700305,0.0001060501,0.000161484,0.00013935,0.0001717062,0.0001493936,0.0001481471,0.0004422562,0.0007625046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425952,"about_ca_system_score_gemma":0.0001461843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003247651,"about_ca_topic_score_gemma":0.0004108076,"domain_scores_codex":[0.9999101,0.000008467285,0.000008085513,0.00002640265,0.00003105065,0.00001589749],"domain_scores_gemma":[0.9999645,0.000003273464,0.00001387689,0.000003663051,0.000004333753,0.00001045802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007337164,0.00002012512,0.0002662683,0.00004654774,0.000002640921,0.00005253159,0.00001120208,0.00002290763,0.9965714,0.0001292025,0.0002190293,0.002584817],"study_design_scores_gemma":[0.00004364938,0.0004979717,0.016359,0.0000114657,0.00002198404,0.0008063697,0.00005024957,0.0007785044,0.9694251,0.0001164651,0.01188402,0.000005129852],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861173,0.003254025,0.003358432,0.0004263241,0.0001426385,0.00006027254,0.001580269,0.0003208412,0.004739855],"genre_scores_gemma":[0.989827,0.001061674,0.001167954,0.0001431261,0.00002705066,0.00003906083,0.000929222,0.00003046822,0.006774449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002682986,"threshold_uncertainty_score":0.008975446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04073092398452072,"score_gpt":0.3625602808864312,"score_spread":0.3218293569019105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}