{"id":"W2316463379","doi":"10.1021/bc5003357","title":"Dual Mode Fluorescent <sup>18</sup>F-PET Tracers: Efficient Modular Synthesis of Rhodamine-[cRGD]<sub>2</sub>-[<sup>18</sup>F]-Organotrifluoroborate, Rapid, and High Yielding One-Step <sup>18</sup>F-Labeling at High Specific Activity, and Correlated <i>in Vivo</i> PET Imaging and <i>ex Vivo</i> Fluorescence","year":2014,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Genome British Columbia","keywords":"Chemistry; Fluorescence; Yield (engineering); Fluoride; Fluorophore; Radiochemistry; Radiosynthesis; Combinatorial chemistry; In vivo; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008777099,0.001739562,0.001917635,0.0002127162,0.0007825002,0.0004014027,0.000879659,0.0007864358,0.0009340081],"category_scores_gemma":[0.0005285534,0.00198141,0.0003203427,0.0008640303,0.001263272,0.0004533638,0.001046576,0.001456258,0.00002184757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005682558,"about_ca_system_score_gemma":0.0001814969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002744262,"about_ca_topic_score_gemma":0.00000703859,"domain_scores_codex":[0.9919752,0.0001691079,0.001934624,0.003044728,0.001071321,0.001804971],"domain_scores_gemma":[0.9943952,0.001336287,0.0009699346,0.001948208,0.0003702101,0.0009801595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005400512,0.0008428622,0.0009470753,0.002357192,0.0002209291,0.000133376,0.0004452028,0.01323046,0.9757357,0.00003251791,0.001103572,0.004411065],"study_design_scores_gemma":[0.003103502,0.00003458778,0.00006322483,0.001353648,0.000318767,0.0003996295,0.0008060649,0.1999928,0.7917003,0.00005519824,0.0006316875,0.001540622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938204,0.001382297,0.000221268,0.0005038554,0.00005597829,0.0008410072,0.001480425,0.0003703581,0.001324367],"genre_scores_gemma":[0.9938971,0.002948167,0.001461801,0.00007922883,0.0005255009,0.0002864868,0.0002811885,0.000288739,0.0002317969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1867623,"threshold_uncertainty_score":0.9999793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122435177475991,"score_gpt":0.2141472989952078,"score_spread":0.2029229472204479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}