{"id":"W2316469384","doi":"10.1038/sj.gt.3301396","title":"Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Hamilton Health Sciences","keywords":"CTL*; Immune system; Genetic enhancement; Immunology; Cytotoxic T cell; CD8; Cancer research; Biology; Immunization; ErbB; Dendritic cell; Immunity; Acquired immune system; Cancer; Medicine; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004210346,0.0007841995,0.0006295206,0.0005107428,0.0002004386,0.0005936683,0.0003107586,0.0006663025,0.001008992],"category_scores_gemma":[0.000216129,0.0002995101,0.0004271564,0.0003413265,0.000452171,0.0004299403,0.0002903548,0.001960317,0.0004514249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004132728,"about_ca_system_score_gemma":0.000335189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003249757,"about_ca_topic_score_gemma":0.0003551995,"domain_scores_codex":[0.9997037,0.00005206107,0.00003010547,0.00004150512,0.00006099106,0.0001115036],"domain_scores_gemma":[0.9998109,0.00004790894,0.00004113205,0.0000391215,0.00001593574,0.00004502891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006387796,0.0002691872,0.0000895419,0.00004191073,0.000008867371,0.00004650728,0.00001953256,0.000250728,0.995595,0.0002950787,0.00006879402,0.002675944],"study_design_scores_gemma":[0.0001016829,0.0004577345,0.0003422963,0.000002928945,0.00002387119,0.00009465797,0.000006675826,0.0009741978,0.9972395,0.00004711483,0.0007060781,0.000003267334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891639,0.001837216,0.006166716,0.0002310678,0.0001420234,0.0001398054,0.0003190004,0.0002198487,0.001780526],"genre_scores_gemma":[0.9943817,0.0007532461,0.002998085,0.00005003575,0.00003515767,0.00007894041,0.0002200398,0.00003148603,0.001451271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001008992,"threshold_uncertainty_score":0.003375411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03589684090892933,"score_gpt":0.2624634454839267,"score_spread":0.2265666045749974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}