{"id":"W2316469384","doi":"10.1038/sj.gt.3301396","title":"Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene encoding IL-12","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":76,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Hamilton Health Sciences","keywords":"CTL*; Immune system; Genetic enhancement; Immunology; Cytotoxic T cell; CD8; Cancer research; Biology; Immunization; ErbB; Dendritic cell; Immunity; Acquired immune system; Cancer; Medicine; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004155303,0.0003118631,0.0005399031,0.0002166959,0.0002946036,0.00001624969,0.0002358965,0.0002971638,0.0001549061],"category_scores_gemma":[0.00001326274,0.0002933529,0.0001417268,0.0002846891,0.00058396,0.0001117428,0.00002345804,0.0003431079,0.000005735536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005484245,"about_ca_system_score_gemma":0.0000776587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001504904,"about_ca_topic_score_gemma":0.000001890414,"domain_scores_codex":[0.997815,0.0007146975,0.0006061037,0.0003769845,0.00008699196,0.0004002248],"domain_scores_gemma":[0.9989288,0.0001381821,0.0003068197,0.0004367494,0.0001668373,0.00002262204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004399824,0.0004181422,0.00003229055,0.00001822173,0.0003767103,0.000001067623,0.002337729,0.0001708134,0.9549783,0.00002850984,0.000003552092,0.03723481],"study_design_scores_gemma":[0.003695558,0.0009587074,0.003258573,0.00005093978,0.00004317908,0.0001252781,0.0004115438,0.00002573703,0.9905667,0.00009755308,0.0004865422,0.0002796449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530547,0.033331,0.01220316,0.00002890391,0.000486895,0.0007844147,0.00003190733,0.00004397727,0.00003500884],"genre_scores_gemma":[0.9850211,0.01432939,0.0004079414,0.00003297565,0.00003544577,0.00002104367,0.00002578142,0.00004283056,0.00008353348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03695516,"threshold_uncertainty_score":0.9999518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03589684090892933,"score_gpt":0.2624634454839267,"score_spread":0.2265666045749974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}