{"id":"W2316563496","doi":"10.1097/shk.0b013e31824582e6","title":"NADPH Oxidase–Derived Superoxide Destabilizes Lipopolysaccharide-Induced Interleukin 8 mRNA Via p38, Extracellular Signal–Regulated Kinase Mitogen-Activated Protein Kinase, and the Destabilizing Factor Tristetraprolin","year":2012,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Tristetraprolin; NADPH oxidase; p38 mitogen-activated protein kinases; Protein kinase A; Chemistry; Kinase; Molecular biology; MAPK/ERK pathway; Apocynin; Tumor necrosis factor alpha; Superoxide; Cell biology; Biology; Biochemistry; Messenger RNA; Reactive oxygen species; Immunology; Enzyme; RNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008802937,0.000874996,0.00102307,0.0002898232,0.0007317703,0.00010597,0.0006076354,0.0006340351,0.001097979],"category_scores_gemma":[0.0003062102,0.0006297456,0.0003363244,0.0004219139,0.000768363,0.0005964061,0.0003140004,0.001051649,0.0002171464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002047898,"about_ca_system_score_gemma":0.0001365366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005597356,"about_ca_topic_score_gemma":0.00007779261,"domain_scores_codex":[0.9949185,0.001558821,0.000982209,0.0009208785,0.0001804609,0.001439076],"domain_scores_gemma":[0.9976922,0.0005907943,0.0003778246,0.0008844036,0.000228384,0.0002263705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001726242,0.0003334436,0.0003028623,0.00006120964,0.0003621057,0.00002833646,0.002247167,0.000001076732,0.9865381,0.0009903165,0.00002943235,0.007379676],"study_design_scores_gemma":[0.005657846,0.0004716133,0.0004769526,0.0001456742,0.0001560133,0.0001097566,0.001224983,0.00002841674,0.9892636,0.0004302091,0.00126097,0.0007739778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867424,0.008048728,0.001357082,0.0003208825,0.000780522,0.002363792,0.0000631127,0.000281687,0.00004180178],"genre_scores_gemma":[0.9980208,0.00005491782,0.0004076392,0.0001617427,0.000134888,0.0002584318,0.0001030424,0.0001296591,0.0007288954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01127839,"threshold_uncertainty_score":0.9998152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092895406498349,"score_gpt":0.2319332131825496,"score_spread":0.2110042591175662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}