{"id":"W2316563496","doi":"10.1097/shk.0b013e31824582e6","title":"NADPH Oxidase–Derived Superoxide Destabilizes Lipopolysaccharide-Induced Interleukin 8 mRNA Via p38, Extracellular Signal–Regulated Kinase Mitogen-Activated Protein Kinase, and the Destabilizing Factor Tristetraprolin","year":2012,"lang":"en","type":"article","venue":"Shock","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Tristetraprolin; NADPH oxidase; p38 mitogen-activated protein kinases; Protein kinase A; Chemistry; Kinase; Molecular biology; MAPK/ERK pathway; Apocynin; Tumor necrosis factor alpha; Superoxide; Cell biology; Biology; Biochemistry; Messenger RNA; Reactive oxygen species; Immunology; Enzyme; RNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002876069,0.0004223305,0.00018986,0.0002474491,0.0001582851,0.0002453042,0.0001945011,0.0002091354,0.001042166],"category_scores_gemma":[0.0002453716,0.0001683244,0.0003264532,0.0001100236,0.0002079906,0.0002277791,0.0001645894,0.0005168353,0.0002836702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660846,"about_ca_system_score_gemma":0.00019311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002209406,"about_ca_topic_score_gemma":0.0003203789,"domain_scores_codex":[0.9997908,0.00004085616,0.00002081308,0.00005077295,0.00005697928,0.00003965709],"domain_scores_gemma":[0.9997951,0.00002298929,0.0001091924,0.00001509041,0.00002795249,0.00002962502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007243086,0.00001305993,0.00005569473,0.00002488852,0.000002670032,0.00003145528,0.000009238764,0.00001439963,0.9993,0.00004756514,0.00001451669,0.0004141011],"study_design_scores_gemma":[0.00002078787,0.0002565128,0.004328642,0.000007721544,0.00001733824,0.0002643071,0.00002038753,0.0007278204,0.9927988,0.00007557036,0.001476521,0.000005521435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801769,0.004110243,0.01328815,0.0002837199,0.0001448798,0.00007851665,0.0003026416,0.0002099244,0.001404911],"genre_scores_gemma":[0.9876636,0.001550873,0.007288538,0.0001402851,0.0000545567,0.0001580013,0.0007233177,0.00003600208,0.002384937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042166,"threshold_uncertainty_score":0.003486335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02092895406498349,"score_gpt":0.2319332131825496,"score_spread":0.2110042591175662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}