{"id":"W2316564286","doi":"10.1158/1538-7445.am2013-3191","title":"Abstract 3191: The Akt-mTOR axis determines cell fate through the regulation of eIF2α phosphorylation pathway.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; eIF2; Phosphorylation; Cell biology; Biology; Cancer research; Signal transduction; Programmed cell death; Translation (biology); Apoptosis; Biochemistry; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008452434,0.0003736613,0.0001662086,0.0003681236,0.0004429118,0.0005876049,0.000363566,0.0003575382,0.02567852],"category_scores_gemma":[0.00006632437,0.0001351958,0.0001353699,0.000314987,0.000250365,0.0003928237,0.0002565437,0.0005563179,0.006724667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004808091,"about_ca_system_score_gemma":0.0003457313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008625897,"about_ca_topic_score_gemma":0.001754719,"domain_scores_codex":[0.9999342,0.000003981369,0.000003939454,0.00002003363,0.00002561927,0.00001216433],"domain_scores_gemma":[0.9999665,0.000003411498,0.000007140928,0.000002358537,0.000009311501,0.00001126357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006916845,0.0001068466,0.0007627062,0.0004790649,0.00001886717,0.0006798646,0.00005105955,0.0002278383,0.9344085,0.004820317,0.0215288,0.0362244],"study_design_scores_gemma":[0.0001437791,0.0004825952,0.05156062,0.0001676483,0.000067596,0.002533586,0.0001978136,0.00174741,0.5945324,0.003777803,0.3447556,0.00003306212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5312043,0.07438903,0.01897588,0.01298471,0.01339287,0.0003078881,0.02027817,0.002919806,0.3255473],"genre_scores_gemma":[0.6533164,0.01742199,0.004710281,0.001172505,0.001628382,0.0001303288,0.01045372,0.0001931412,0.3109733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02567852,"threshold_uncertainty_score":0.08590317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03179789244354278,"score_gpt":0.3263549287465309,"score_spread":0.2945570363029881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}