{"id":"W2316570582","doi":"10.1097/cad.0b013e32835cbde7","title":"Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9","year":2012,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; Université de Sherbrooke","funders":"","keywords":"Bone morphogenetic protein; Phosphorylation; Osteosarcoma; MAPK/ERK pathway; p38 mitogen-activated protein kinases; Chemistry; Kinase; Protein kinase A; Bone morphogenetic protein 2; SMAD; Cell biology; Bone morphogenetic protein 7; Cancer research; Mitogen-activated protein kinase; Molecular biology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002696684,0.000114573,0.000116041,0.00003786817,0.0001520834,0.00001944838,0.0001478557,0.0000538278,0.00001839516],"category_scores_gemma":[0.00005991181,0.00009042401,0.00004267886,0.00008839962,0.00009841062,0.000009885764,0.0001261398,0.00004996,0.000002517207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007380717,"about_ca_system_score_gemma":0.00005168497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001027857,"about_ca_topic_score_gemma":0.00001141437,"domain_scores_codex":[0.9991432,0.000115497,0.0001943688,0.0001902184,0.0001434603,0.0002132868],"domain_scores_gemma":[0.9994584,0.00003124572,0.0001342556,0.0002510207,0.00005875804,0.0000663515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004527764,0.00005239802,0.0271826,0.00004390926,0.00003303631,1.054197e-7,0.0005299771,0.00002617518,0.9703208,0.000008118032,0.0001426674,0.001614921],"study_design_scores_gemma":[0.000165933,0.00007670857,0.06509013,0.00006038437,0.00002390172,7.7057e-7,0.0002030375,0.000001696112,0.9314703,0.000007893918,0.002788369,0.0001109035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970931,0.002274678,0.0000381629,0.0001138554,0.00004643417,0.0003536161,0.00001708909,0.000008373894,0.00005466706],"genre_scores_gemma":[0.9988558,0.00005808736,0.000293399,0.0001645502,0.0001803728,0.00008723599,0.000009606801,0.00001645977,0.0003345481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03885055,"threshold_uncertainty_score":0.3687384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01543505804511903,"score_gpt":0.2940673297100402,"score_spread":0.2786322716649212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}