{"id":"W2316641879","doi":"10.1021/bi400951q","title":"Unraveling the Substrate Recognition Mechanism and Specificity of the Unusual Glycosyl Hydrolase Family 29 BT2192 from <i>Bacteroides thetaiotaomicron</i>","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Saskatchewan","keywords":"Bacteroides thetaiotaomicron; Hydrolase; Glycosyl; Galactoside; Chemistry; Glycoside hydrolase; Stereochemistry; Moiety; Active site; Enzyme; Binding site; Fucose; Biochemistry; Substrate (aquarium); Bacteroides; Biology; Galactose; Genetics; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003670623,0.0001855133,0.0001457617,0.00001593765,0.0001780938,0.00005477391,0.0003403618,0.0002061205,0.00002709242],"category_scores_gemma":[0.0001803077,0.000123185,0.0001072893,0.00009205792,0.0002159653,0.000004969883,0.0001991245,0.0002075339,0.000009048721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001393904,"about_ca_system_score_gemma":0.00007089471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001203828,"about_ca_topic_score_gemma":0.00002900445,"domain_scores_codex":[0.9987748,0.0001230932,0.000262377,0.0003849142,0.000223114,0.0002317087],"domain_scores_gemma":[0.9990519,0.00004145509,0.0001507007,0.0005560192,0.0001211993,0.00007878023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009638872,0.00003259725,0.0003700077,0.00002064271,0.00003052516,4.468298e-7,0.00002660505,0.000003686039,0.9964588,0.00003213722,0.0001814561,0.002746714],"study_design_scores_gemma":[0.0004862658,0.00005053475,0.002476766,0.00003267234,0.00001925096,0.000008065758,0.0001398065,0.000303899,0.9932837,0.001062822,0.001980496,0.0001557196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971924,0.0004315115,0.0004813844,0.0002968737,0.00009140291,0.000207153,0.0001366989,0.00001023614,0.001152328],"genre_scores_gemma":[0.9985942,0.0001795881,0.0001971152,0.0002162638,0.0002755623,0.00001469282,0.0001451979,0.00002039967,0.0003569862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003175092,"threshold_uncertainty_score":0.5023338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334943908215406,"score_gpt":0.2204527346982854,"score_spread":0.2071032956161313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}