{"id":"W2316649866","doi":"10.1097/00004714-200008000-00008","title":"Inhibition of Cytochrome P450 2D6 Modifies Codeine Abuse Liability","year":2000,"lang":"en","type":"article","venue":"Journal of Clinical Psychopharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Sunnybrook Health Science Centre; Health Sciences Centre; University of Toronto","funders":"National Institute on Drug Abuse","keywords":"Codeine; Quinidine; Pharmacology; Morphine; Placebo; Medicine; Anesthesia; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005914683,0.0003918861,0.00159252,0.0002846783,0.0001400645,0.00001437169,0.0006536225,0.000789916,0.01799055],"category_scores_gemma":[0.0003627823,0.0003418125,0.0009003204,0.0004425319,0.001000912,0.0002668365,0.0000557761,0.002502287,0.000219442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000453418,"about_ca_system_score_gemma":0.0002982838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000495377,"about_ca_topic_score_gemma":0.000002340625,"domain_scores_codex":[0.9920737,0.002335968,0.00404039,0.0004545564,0.0004782031,0.0006172345],"domain_scores_gemma":[0.9942657,0.002076723,0.001785787,0.0003305752,0.0007479095,0.0007933312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03424179,0.009844732,0.01084051,0.0002415458,0.002171765,0.0004975582,0.00137533,0.00757377,0.6487945,0.0003035843,0.0485777,0.2355373],"study_design_scores_gemma":[0.03800013,0.002317321,0.04389748,0.00006902326,0.001772304,0.000324657,0.00008137492,0.00260155,0.07579414,0.00525155,0.8291834,0.0007070441],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819614,0.00197218,0.0001073937,0.001622785,0.004989762,0.0004419615,0.0001036344,0.00003472704,0.008766115],"genre_scores_gemma":[0.9747376,0.01527017,0.0006194936,0.005668116,0.002770391,0.00001511349,0.000007570299,0.00004156617,0.0008699847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7806057,"threshold_uncertainty_score":0.9999034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1748321756079306,"score_gpt":0.5378821078846676,"score_spread":0.363049932276737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}