{"id":"W2316779971","doi":"10.1139/bcb-2013-0090","title":"Different redox sensitivity of endoplasmic reticulum associated degradation clients suggests a novel role for disulphide bonds in secretory proteins","year":2014,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Endoplasmic-reticulum-associated protein degradation; Endoplasmic reticulum; Protein disulfide-isomerase; Chemistry; Proteostasis; Protein folding; Secretory pathway; Biochemistry; Cytosol; Dithiothreitol; Unfolded protein response; Cell biology; Biophysics; Enzyme; Biology; Golgi apparatus","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472216,0.0001884811,0.0002248539,0.0001959908,0.0001230829,0.0003551873,0.0002308527,0.0003277874,0.001166222],"category_scores_gemma":[0.00009676358,0.0001068546,0.0002782152,0.0001361168,0.0001930338,0.0003012792,0.0001535441,0.0003244807,0.0002107034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282976,"about_ca_system_score_gemma":0.00007082976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003324857,"about_ca_topic_score_gemma":0.0002811256,"domain_scores_codex":[0.9999157,0.000009035479,0.000007691983,0.00003075869,0.00002103217,0.00001577687],"domain_scores_gemma":[0.9999334,0.000008544953,0.00001642321,0.000008404039,0.00001626314,0.00001696856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001076894,0.000008036684,0.0004936529,0.00001627085,0.000005362769,0.00003243281,0.00001262034,0.00002054317,0.9986106,0.00009349486,0.000009547558,0.0005897182],"study_design_scores_gemma":[0.000008660935,0.0002116384,0.04496484,0.000006364298,0.00002653344,0.0007793609,0.00007629474,0.0007986571,0.9514452,0.0002825921,0.001389281,0.0000105539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950537,0.001839723,0.001936338,0.00009714832,0.00001128866,0.000006296691,0.0001712012,0.00002927341,0.0008550883],"genre_scores_gemma":[0.997349,0.0006249564,0.0008462772,0.00006045489,0.00000537711,0.000004198226,0.000252345,0.000007789246,0.0008495529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166222,"threshold_uncertainty_score":0.003901422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005328764732303478,"score_gpt":0.2192331046296381,"score_spread":0.2139043398973346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}