{"id":"W2316794472","doi":"10.1016/j.juro.2013.02.574","title":"992 A PARACRINE HEDGEHOG SIGNALING MICROENVIRONMENT IN ADT-TREATED PROSTATE TUMORS INDUCES STEROIDOGENESIS FROM BENIGN PROSTATE STROMAL CELLS","year":2013,"lang":"en","type":"article","venue":"The Journal of Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Paracrine signalling; Stromal cell; Prostate cancer; Medicine; Hedgehog; Cancer research; Hedgehog signaling pathway; Androgen; Androgen receptor; Androgen deprivation therapy; Tumor microenvironment; Internal medicine; Endocrinology; Prostate; Sonic hedgehog; Cancer; Biology; Signal transduction; Cell biology; Hormone; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007733865,0.000198984,0.0002216574,0.0003671654,0.0002469464,0.0003495264,0.0001361891,0.0001965895,0.005466591],"category_scores_gemma":[0.00004733583,0.0001527842,0.0003608829,0.000268761,0.0001818833,0.000141944,0.0001642457,0.0007297356,0.001096369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003278989,"about_ca_system_score_gemma":0.0004499746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00163017,"about_ca_topic_score_gemma":0.00368195,"domain_scores_codex":[0.9998165,0.00001652545,0.00001281278,0.00002232428,0.00007612703,0.00005567576],"domain_scores_gemma":[0.9999321,0.00001005846,0.000007282506,0.000007092868,0.000009563968,0.00003392872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000240957,0.0001612476,0.000761098,0.0000778778,0.000009620757,0.0002376765,0.00002516952,0.00004089892,0.9921815,0.0001578415,0.0005996241,0.005506549],"study_design_scores_gemma":[0.00003747115,0.0008009355,0.01451217,0.00001102864,0.00001976528,0.0008971062,0.0001041989,0.0003431096,0.9721392,0.00005933087,0.01106772,0.000007988368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698697,0.00874567,0.00252272,0.000756507,0.0003038673,0.000140723,0.002274549,0.0003112869,0.01507489],"genre_scores_gemma":[0.9744727,0.00280538,0.002162913,0.0002731165,0.00005761271,0.00006129145,0.001969963,0.00004375986,0.01815327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005466591,"threshold_uncertainty_score":0.01828754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772885349299453,"score_gpt":0.2542773712023228,"score_spread":0.2365485177093283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}