{"id":"W2316803818","doi":"10.1128/mbio.02242-15","title":"Gliotoxin Suppresses Macrophage Immune Function by Subverting Phosphatidylinositol 3,4,5-Trisphosphate Homeostasis","year":2016,"lang":"en","type":"article","venue":"mBio","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Gliotoxin; Macrophage; Homeostasis; Immune system; Phosphatidylinositol; Cell biology; Function (biology); Phagocytosis; Immunology; Chemistry; Biology; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001803801,0.000264186,0.0002171839,0.0001073898,0.0003792905,0.0001635317,0.00031581,0.00009821774,0.001386138],"category_scores_gemma":[0.0004939092,0.0002021207,0.0001086768,0.0003943373,0.00007869424,0.0005928313,0.000099392,0.0001325075,0.0009887737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004422084,"about_ca_system_score_gemma":0.00002992891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009664748,"about_ca_topic_score_gemma":0.000002100011,"domain_scores_codex":[0.9977402,0.0002019251,0.0004979071,0.0006641206,0.0004461455,0.0004496741],"domain_scores_gemma":[0.9988317,0.0002623371,0.0002407742,0.0004484681,0.00005929278,0.000157368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041129,0.00005863878,0.00007202429,0.00001101094,0.000003167512,0.00002335394,0.00003038876,0.000004127495,0.9762222,0.002016963,0.004950698,0.01650329],"study_design_scores_gemma":[0.0009718533,0.0001206204,0.0002394413,0.00002182737,0.00001215367,0.00001578434,0.000008099983,0.0001337882,0.9732782,0.0002604935,0.02467571,0.0002619979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862093,0.0003728491,0.008104987,0.001931848,0.001557376,0.0004780467,0.0001158057,0.0005357291,0.0006941078],"genre_scores_gemma":[0.9924925,0.0004174937,0.00008847451,0.001282492,0.00008963048,0.00004435892,0.000008338308,0.00005172914,0.005524989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01972501,"threshold_uncertainty_score":0.9997891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409868222447996,"score_gpt":0.225846808007587,"score_spread":0.211748125783107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}