{"id":"W2316879696","doi":"10.1021/mp200028w","title":"Bisphosphonate-Derivatized Liposomes to Control Drug Release from Collagen/Hydroxyapatite Scaffolds","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Liposome; Chemistry; PEG ratio; Drug delivery; Ethylene glycol; Drug; Controlled release; Drug carrier; Bisphosphonate; Pharmacology; Bioavailability; Biophysics; Biochemistry; Medicine; Organic chemistry; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592492,0.0003859471,0.0002926747,0.0001923019,0.0001020976,0.0003523044,0.0002362842,0.0003479739,0.0005020454],"category_scores_gemma":[0.0002237355,0.0002047727,0.0001758071,0.0001131267,0.0001993986,0.0002887124,0.0002128007,0.0004845046,0.0002238353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262079,"about_ca_system_score_gemma":0.0002179688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005644646,"about_ca_topic_score_gemma":0.0007261224,"domain_scores_codex":[0.9998016,0.00003185595,0.00002675302,0.00005594846,0.00005099152,0.00003293921],"domain_scores_gemma":[0.9998099,0.00005146785,0.00005920954,0.00001689137,0.00002944915,0.00003302684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002649206,0.000007501131,0.00001933428,0.00002260577,0.000001833665,0.00001225281,0.000004665649,0.00005726204,0.9991767,0.00003069325,0.000007421521,0.0006333608],"study_design_scores_gemma":[0.00001086411,0.00004747323,0.0001645714,0.000001443943,0.000005334579,0.0000420187,0.000001830908,0.0005309249,0.9984817,0.000005886304,0.0007054171,0.000002638349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9615024,0.004007197,0.03267491,0.000145042,0.0001117943,0.0001632119,0.0002675979,0.0002611414,0.0008668801],"genre_scores_gemma":[0.9660235,0.001398333,0.02968055,0.0001068889,0.00003036627,0.0001428023,0.0002525678,0.00006970265,0.00229524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005644646,"threshold_uncertainty_score":0.003092349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380385001965834,"score_gpt":0.2224712112426633,"score_spread":0.2086673612230049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}