{"id":"W2316914892","doi":"10.1021/bi401051j","title":"The Role of Basic Amino Acid Surface Clusters on the Collagenase Activity of Cathepsin K","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research","keywords":"Biochemistry; Cathepsin; Cathepsin C; Cathepsin L; Amino acid; Cathepsin O; Chemistry; Cathepsin A; Protease; Cathepsin K; Arginine; Glycosaminoglycan; Lysine; Microbial collagenase; Collagenase; Mutant; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315422,0.0001343286,0.0001237561,0.000005562968,0.00008989123,0.00001657085,0.0003097123,0.0001030181,0.00003273718],"category_scores_gemma":[0.0001575918,0.00008050779,0.0001189478,0.00006870352,0.0002582246,0.000002412462,0.0001090412,0.00005666415,0.000008212098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006321089,"about_ca_system_score_gemma":0.00009739313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007822763,"about_ca_topic_score_gemma":0.000003868419,"domain_scores_codex":[0.9992624,0.00005680591,0.0001531597,0.0002043331,0.0001491396,0.0001741766],"domain_scores_gemma":[0.9989872,0.00005362737,0.0001424568,0.0006593456,0.00009161736,0.00006575962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000887822,0.00009277523,0.0005960074,0.0000203387,0.00003330329,1.633452e-7,0.00001635698,0.000005546977,0.9943617,0.00002737639,0.003308482,0.001449189],"study_design_scores_gemma":[0.0001804937,0.00004200988,0.002267706,0.000009536164,0.00001922449,0.000001143487,0.0002669804,0.00003058463,0.9944049,0.00004861423,0.002637313,0.00009155092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946189,0.002769737,0.000005521249,0.0002430529,0.00004787598,0.0001689013,0.00007504471,0.000004802449,0.002066182],"genre_scores_gemma":[0.9989482,0.0001290323,0.00002653773,0.00008261552,0.00006760246,0.00001895221,0.00001844885,0.00001221189,0.0006963993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004329317,"threshold_uncertainty_score":0.3283013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005545339725690418,"score_gpt":0.2046666984858209,"score_spread":0.1991213587601305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}