{"id":"W2316914892","doi":"10.1021/bi401051j","title":"The Role of Basic Amino Acid Surface Clusters on the Collagenase Activity of Cathepsin K","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research","keywords":"Biochemistry; Cathepsin; Cathepsin C; Cathepsin L; Amino acid; Cathepsin O; Chemistry; Cathepsin A; Protease; Cathepsin K; Arginine; Glycosaminoglycan; Lysine; Microbial collagenase; Collagenase; Mutant; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433153,0.0003063911,0.0002400617,0.0001284218,0.0001287127,0.00026914,0.0002750619,0.0003528293,0.0005795358],"category_scores_gemma":[0.0001692135,0.0001241139,0.0002679068,0.00009151834,0.0003335674,0.0001893229,0.0002120347,0.0002716662,0.0002777395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567395,"about_ca_system_score_gemma":0.0002189816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136237,"about_ca_topic_score_gemma":0.0008573111,"domain_scores_codex":[0.9998497,0.00003389388,0.00001448587,0.00002509991,0.00003962883,0.00003722791],"domain_scores_gemma":[0.9997435,0.00004622112,0.00007588569,0.00003042135,0.00002914451,0.00007471732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002103779,0.000007939743,0.0007169031,0.00001560008,0.00000546736,0.00008300099,0.00001312653,0.00008697939,0.9983095,0.00004106206,0.000006371165,0.0005035947],"study_design_scores_gemma":[0.00002900811,0.0003475785,0.0465676,0.00001100176,0.00003322864,0.001251463,0.00006365971,0.00114341,0.9495915,0.00007480923,0.0008717776,0.00001485122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988614,0.0003469385,0.0004178478,0.00002159172,0.00000323206,0.000004857902,0.00004553084,0.000009900266,0.00028858],"genre_scores_gemma":[0.9991024,0.0001270361,0.0004172118,0.00001056478,0.000001932777,0.000003675784,0.00006961534,0.000005556703,0.0002621079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136237,"threshold_uncertainty_score":0.002259254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005545339725690418,"score_gpt":0.2046666984858209,"score_spread":0.1991213587601305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}