{"id":"W2316945952","doi":"10.1055/s-0031-1296371","title":"A Single-dose, Randomized, Open-label, Two-period Crossover Bioequivalence Study Comparing a Fixed-Dose Pediatric Combination of Lamivudine and Stavudine Tablet for Oral Suspension with Individual Liquid Formulations in Healthy Adult Male Volunteers","year":2011,"lang":"en","type":"article","venue":"Arzneimittelforschung","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada); Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Stavudine; Lamivudine; Bioequivalence; Fixed-dose combination; Pharmacology; Pharmacokinetics; Crossover study; Medicine; Zidovudine; Reverse-transcriptase inhibitor; Human immunodeficiency virus (HIV); Virology; Sida; Virus; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004173335,0.002436449,0.005611747,0.0007938691,0.000634419,0.001172881,0.001649668,0.002831916,0.004120138],"category_scores_gemma":[0.003441613,0.001535018,0.002056757,0.0007824211,0.002306382,0.001815685,0.0005553391,0.003096791,0.001157061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000873659,"about_ca_system_score_gemma":0.00185128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009269963,"about_ca_topic_score_gemma":0.001317193,"domain_scores_codex":[0.9971836,0.001200004,0.0002205683,0.0007733866,0.0003886643,0.0002337075],"domain_scores_gemma":[0.9975795,0.0005597853,0.0005434927,0.0004145907,0.0003543652,0.000548235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9057428,0.06236871,0.0004994161,0.0005284583,0.000605006,0.00003541889,0.000146339,0.0004132471,0.01949226,0.0001408775,0.0003547689,0.009672714],"study_design_scores_gemma":[0.2870776,0.7042382,0.003259376,0.00001608578,0.0005398098,0.000037274,0.00003523241,0.0006714413,0.0030353,0.0001075234,0.0009323671,0.00004975878],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846156,0.001070057,0.002282329,0.0001764693,0.000456572,0.009239892,0.001084496,0.0001383895,0.0009362248],"genre_scores_gemma":[0.9703286,0.001420982,0.008483679,0.0007348292,0.0005772577,0.01187263,0.001520184,0.00006659518,0.004995333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005611747,"threshold_uncertainty_score":0.022071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07768172737483126,"score_gpt":0.3217633594496312,"score_spread":0.2440816320747999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}