{"id":"W2316945952","doi":"10.1055/s-0031-1296371","title":"A Single-dose, Randomized, Open-label, Two-period Crossover Bioequivalence Study Comparing a Fixed-Dose Pediatric Combination of Lamivudine and Stavudine Tablet for Oral Suspension with Individual Liquid Formulations in Healthy Adult Male Volunteers","year":2011,"lang":"en","type":"article","venue":"Arzneimittelforschung","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada); Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Stavudine; Lamivudine; Bioequivalence; Fixed-dose combination; Pharmacology; Pharmacokinetics; Crossover study; Medicine; Zidovudine; Reverse-transcriptase inhibitor; Human immunodeficiency virus (HIV); Virology; Sida; Virus; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001024812,0.0003716945,0.001163602,0.0005095589,0.0002386818,0.00006660746,0.0001979797,0.0000861833,0.00004458319],"category_scores_gemma":[0.0002421129,0.0002954296,0.00006080923,0.0006960768,0.0001563564,0.0005969881,0.0002414264,0.0001976709,0.000004386599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001403114,"about_ca_system_score_gemma":0.0002179877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006169101,"about_ca_topic_score_gemma":0.001624346,"domain_scores_codex":[0.9974442,0.0001299182,0.0009129736,0.0005531647,0.0004397135,0.0005200588],"domain_scores_gemma":[0.99847,0.0002610756,0.0003821751,0.0003138708,0.0003953288,0.0001775209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2041667,0.007922335,0.7697343,0.0003566079,0.0004894339,0.0000873703,0.01430958,0.00002452672,0.0003260797,0.001790153,0.0001756745,0.0006172865],"study_design_scores_gemma":[0.8577792,0.01196554,0.1158527,0.0004647647,0.001714798,0.0001433393,0.003251147,0.006521824,0.001349473,0.0001777493,0.00004130413,0.0007381528],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923049,0.0002002906,0.0003622248,0.000350691,0.00008469848,0.006210363,0.00003087799,0.00004502115,0.0004109174],"genre_scores_gemma":[0.9857935,0.00006866868,0.01293194,0.00009087264,0.00003037356,0.0004509093,0.0001893735,0.00004852013,0.0003958676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6538816,"threshold_uncertainty_score":0.9999498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07768172737483126,"score_gpt":0.3217633594496312,"score_spread":0.2440816320747999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}