{"id":"W2317025721","doi":"10.1021/jm501357r","title":"Synthesis and Evaluation of Radioiodinated Acyloxymethyl Ketones as Activity-Based Probes for Cathepsin B","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Probe Development and Commercialization; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"Chemistry; Organic chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955451,0.0004353792,0.000280343,0.000176458,0.0001108104,0.0002151668,0.000281765,0.0003003903,0.0007067493],"category_scores_gemma":[0.0001505655,0.0001825023,0.0002231992,0.0001906853,0.0001815654,0.0001977961,0.0001518632,0.0002974949,0.0002256378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003301137,"about_ca_system_score_gemma":0.0001554554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007148161,"about_ca_topic_score_gemma":0.001181856,"domain_scores_codex":[0.999904,0.00002306533,0.000008045106,0.00001901407,0.00002278281,0.00002315708],"domain_scores_gemma":[0.9998975,0.00001545999,0.00002897356,0.00001034484,0.00001850171,0.00002921601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001374745,0.00002209134,0.000116211,0.0000457848,0.000006828323,0.00007151283,0.00001867362,0.0002135329,0.9978563,0.00004987466,0.00002135088,0.001440355],"study_design_scores_gemma":[0.00004848087,0.001119365,0.001180381,0.00000494375,0.00002223147,0.0002580902,0.00002021166,0.0003959086,0.9952915,0.00001497801,0.001633558,0.00001036829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992272,0.003010108,0.00295225,0.00005804923,0.00001912576,0.00006788546,0.0002729571,0.00006989072,0.001277627],"genre_scores_gemma":[0.9914904,0.002094983,0.004378277,0.00004677134,0.000008277169,0.00006250293,0.0003533543,0.000009913706,0.001555593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007148161,"threshold_uncertainty_score":0.002395213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01807493958073627,"score_gpt":0.3002151070920843,"score_spread":0.2821401675113481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}