{"id":"W2317222179","doi":"10.1158/1538-7445.am2012-4844","title":"Abstract 4844: A novel mechanism of immune escape in cancer and its regulation by nitric oxide","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"DU145; Hypoxia (environmental); Immune system; Cancer cell; Cancer research; Gene knockdown; Biology; Cell biology; MHC class I; Immunology; Chemistry; Cancer; Cell culture; Major histocompatibility complex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178471,0.0002291202,0.0001701499,0.0001206113,0.0001577542,0.0002230294,0.0002219799,0.0003570995,0.001363749],"category_scores_gemma":[0.00007955208,0.00007471993,0.0001756846,0.0000833035,0.0001566546,0.0002089753,0.0001768994,0.000348986,0.0002281161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002106152,"about_ca_system_score_gemma":0.0001286068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001950646,"about_ca_topic_score_gemma":0.0001755018,"domain_scores_codex":[0.999928,0.00001353996,0.000004515759,0.00001709116,0.00002201957,0.00001473749],"domain_scores_gemma":[0.999964,0.000005638678,0.00001059118,0.000002937941,0.000006160137,0.00001063304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001845721,0.00005767438,0.0003975504,0.0001846735,0.00001120054,0.0003623405,0.00002614251,0.000168186,0.9871147,0.001614138,0.0005545809,0.009324325],"study_design_scores_gemma":[0.00008007076,0.001002766,0.01770841,0.00004168322,0.00004376675,0.001767125,0.00005347696,0.004717624,0.9389368,0.002109554,0.03351841,0.00002032906],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9110338,0.05731747,0.01733458,0.002186326,0.000854011,0.0001312469,0.0005205058,0.0001710986,0.01045097],"genre_scores_gemma":[0.9796448,0.007901796,0.003147764,0.0003914111,0.0002358649,0.00008768439,0.0003141183,0.00001290548,0.008263691],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001363749,"threshold_uncertainty_score":0.004562199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04627545876435238,"score_gpt":0.3591722026663035,"score_spread":0.3128967439019511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}