{"id":"W2317436031","doi":"10.1021/ol502747t","title":"Resorcylic Acid Lactone Biosynthesis Relies on a Stereotolerant Macrocyclizing Thioesterase","year":2014,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Thioesterase; Chemistry; Lactone; Biosynthesis; Stereochemistry; Enzyme; Substrate (aquarium); Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001360915,0.0003550908,0.0001894923,0.0001806097,0.00007204917,0.0003229057,0.0001473509,0.000150922,0.0004787363],"category_scores_gemma":[0.0001911756,0.0001258386,0.0002148211,0.0001209247,0.0002092966,0.000142215,0.0002561852,0.0002413398,0.0003699739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001567522,"about_ca_system_score_gemma":0.0002617008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004799275,"about_ca_topic_score_gemma":0.0005345853,"domain_scores_codex":[0.9998825,0.00001828266,0.00001091206,0.00003203677,0.00003174552,0.00002457562],"domain_scores_gemma":[0.9998516,0.00001684282,0.0000444595,0.00003294061,0.00002309387,0.0000310666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002989388,0.000004574565,0.0002848917,0.000005070865,0.000001731618,0.0000337954,0.000006172882,0.00002676533,0.9983814,0.00005101377,0.000003563667,0.001171057],"study_design_scores_gemma":[0.000005431024,0.0001452483,0.003248611,0.000002209654,0.000007780465,0.0003873518,0.00002098459,0.0003471464,0.9948329,0.00003349174,0.0009640589,0.000004754417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926053,0.0004940787,0.005373524,0.00005192239,0.00001053901,0.00003153661,0.0001176097,0.00008137288,0.001234013],"genre_scores_gemma":[0.9963793,0.0002555671,0.002354288,0.00001500898,0.000002797232,0.000007553183,0.0001528909,0.00001127031,0.0008213464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004799275,"threshold_uncertainty_score":0.001601577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076022962078547,"score_gpt":0.2206142910206457,"score_spread":0.2098540613998602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}