{"id":"W2317497542","doi":"10.1016/j.toxlet.2011.05.047","title":"Use of PBPK modelling in establishing HTV","year":2011,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Educational Technology and Optimization","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Physiologically based pharmacokinetic modelling; Environmental science; Environmental chemistry; Chemistry; Medicine; Pharmacology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001637501,0.00005582812,0.00009045456,0.0002194142,0.00002818819,0.00001176192,0.0003785058,0.00009578092,0.00001595606],"category_scores_gemma":[0.00004834319,0.00005968736,0.00001764254,0.0002890047,0.00007668621,0.0006234435,0.00007617881,0.0001376948,0.00000612007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002514998,"about_ca_system_score_gemma":0.00002677565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005902644,"about_ca_topic_score_gemma":0.00001571466,"domain_scores_codex":[0.9994069,0.00004655217,0.0001707356,0.0001740712,0.00005342934,0.0001482909],"domain_scores_gemma":[0.9995453,0.0001097953,0.00007463242,0.0002285167,0.00002403739,0.00001769874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003147841,0.000506342,0.09046733,0.00002282702,0.00003647452,0.00005270386,0.009218115,0.3084997,0.01826972,0.5644613,0.002268747,0.006165328],"study_design_scores_gemma":[0.0006584231,0.0001689781,0.05633616,0.00005935876,0.00001483765,0.00004023149,0.0001222172,0.8598625,0.05439029,0.02705357,0.0007730488,0.0005203509],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4679227,0.000009754941,0.5294287,0.002210186,0.0001561891,0.00004546499,2.22883e-7,0.00004179158,0.0001850348],"genre_scores_gemma":[0.7215394,0.000006120285,0.2767034,0.001714116,0.000008057833,0.000007538103,0.00000102936,0.000002979485,0.00001734084],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5513629,"threshold_uncertainty_score":0.243398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027898416142139,"score_gpt":0.2404388995312547,"score_spread":0.1376490579170409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}