{"id":"W2317519811","doi":"10.1038/sj.onc.1205050","title":"Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Eye Institute; National Cancer Institute; National Cancer Research Institute","keywords":"Crystallin; Biology; Downregulation and upregulation; Retinoblastoma; Molecular biology; Lens Fiber; Transgene; Retinoblastoma protein; Cell biology; Apoptosis; Genetically modified mouse; Gene expression; Regulation of gene expression; Cell cycle; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004397111,0.0009278547,0.0006881878,0.001990705,0.0005109912,0.0006386635,0.000745518,0.001249842,0.002364714],"category_scores_gemma":[0.000355472,0.0007089478,0.000799435,0.0005730087,0.0008662365,0.0006439421,0.0004058068,0.001901964,0.0006826466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009131638,"about_ca_system_score_gemma":0.0004529348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319141,"about_ca_topic_score_gemma":0.002255167,"domain_scores_codex":[0.9993536,0.00007748105,0.00009015646,0.0001625758,0.0001340209,0.0001821561],"domain_scores_gemma":[0.9990012,0.0002006895,0.0004162602,0.0001177306,0.00006004502,0.0002041572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002913489,0.00005188724,0.0001499023,0.00002249933,0.00001121819,0.000141715,0.00002294374,0.00007485335,0.9981262,0.0004348451,0.00005368212,0.0006188708],"study_design_scores_gemma":[0.00004781388,0.000111587,0.001035908,0.000005346631,0.00001956037,0.000307328,0.00002271478,0.0006333522,0.9967048,0.00008743114,0.001019549,0.000004624264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853145,0.001809297,0.007706814,0.000505994,0.000109091,0.00008168526,0.001314418,0.0005243772,0.002633871],"genre_scores_gemma":[0.9835395,0.001246975,0.004999008,0.00011076,0.00003587432,0.0001325768,0.0008360645,0.0002025586,0.00889679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002364714,"threshold_uncertainty_score":0.007910788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825694439632421,"score_gpt":0.2233421038704237,"score_spread":0.2050851594740995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}