{"id":"W2317538561","doi":"10.1021/mp200176v","title":"Induction of Apoptosis by Survivin Silencing through siRNA Delivery in a Human Breast Cancer Cell Line","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Survivin; Small interfering RNA; Downregulation and upregulation; Gene silencing; Chemistry; Apoptosis; Cancer research; Polyethylenimine; Cancer cell; Cell biology; Transfection; Cancer; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002920216,0.0003249302,0.0005095908,0.0002879468,0.0001977261,0.0003320362,0.0002248681,0.0002692462,0.0008001564],"category_scores_gemma":[0.0001898582,0.0001658473,0.0002467555,0.0004239058,0.0001433529,0.0001363687,0.0001136536,0.0004922936,0.0006924203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004806916,"about_ca_system_score_gemma":0.000351204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00256026,"about_ca_topic_score_gemma":0.002679144,"domain_scores_codex":[0.999728,0.00005339188,0.00003739995,0.00004895497,0.00009497449,0.00003716542],"domain_scores_gemma":[0.9999006,0.00002528742,0.00001284547,0.00001876293,0.0000342578,0.000008279806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001260486,0.00007266949,0.0002167023,0.00005433509,0.000009275642,0.00008900409,0.00003907981,0.0001046376,0.9963759,0.00007682583,0.0001409795,0.002694676],"study_design_scores_gemma":[0.00001745639,0.0003544643,0.0008289186,0.000003486466,0.00002452014,0.0003359471,0.00001773536,0.0009797793,0.9949573,0.00001359864,0.002463709,0.000003088567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701675,0.007825223,0.01567245,0.0002987391,0.00008877575,0.0002145334,0.001152009,0.0002812312,0.00429936],"genre_scores_gemma":[0.970153,0.006087161,0.01402035,0.0001245388,0.00001787294,0.0001755002,0.002847245,0.00004625209,0.006528011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00256026,"threshold_uncertainty_score":0.005090714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03972720929139667,"score_gpt":0.3046345312263642,"score_spread":0.2649073219349676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}