{"id":"W2317538561","doi":"10.1021/mp200176v","title":"Induction of Apoptosis by Survivin Silencing through siRNA Delivery in a Human Breast Cancer Cell Line","year":2011,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Survivin; Small interfering RNA; Downregulation and upregulation; Gene silencing; Chemistry; Apoptosis; Cancer research; Polyethylenimine; Cancer cell; Cell biology; Transfection; Cancer; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370338,0.0002006843,0.000189279,0.00004135845,0.00003988171,0.000008584451,0.000240109,0.00017202,0.0001266125],"category_scores_gemma":[0.000005308521,0.0002159296,0.000102078,0.000135144,0.00007100213,0.00001518681,0.000119279,0.0001543487,0.000003409723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004035179,"about_ca_system_score_gemma":0.00005846823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002129933,"about_ca_topic_score_gemma":0.0001549591,"domain_scores_codex":[0.9988059,0.00009310294,0.0003287276,0.0003409944,0.000151333,0.0002799114],"domain_scores_gemma":[0.999386,0.000003791531,0.000140237,0.0002706314,0.0001365358,0.00006277503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008270469,0.0002445039,0.002310617,0.00003795631,0.00006101605,0.000003251789,0.0003325292,0.000112957,0.9950845,0.000008560454,0.0004340348,0.001287332],"study_design_scores_gemma":[0.0006338647,0.0001514878,0.0003408184,0.00003568749,0.00005367751,0.000005657419,0.0002467154,0.0001226502,0.9977837,0.00002538112,0.0003665944,0.0002337261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951509,0.002189622,0.001141756,0.00002662289,0.0001633172,0.0001571024,0.00009335772,0.000009496523,0.001067879],"genre_scores_gemma":[0.9969569,0.002163198,0.0002228899,0.0003553936,0.00006370198,0.00002298615,0.00007674861,0.00003189961,0.0001063085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002699203,"threshold_uncertainty_score":0.8805352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03972720929139667,"score_gpt":0.3046345312263642,"score_spread":0.2649073219349676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}