{"id":"W2317549718","doi":"10.1093/protein/gzu052","title":"Design and characterization of a novel human Granzyme B inhibitor","year":2014,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Serpin; Granzyme B; Extracellular; Mutagenesis; Wild type; Biology; Granzyme; Immune system; Mutant; Cell biology; Genetics; T cell; Perforin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002942694,0.0001027509,0.00009720113,0.0000668001,0.00006147468,0.00001882977,0.00002486384,0.00009169638,0.000001675886],"category_scores_gemma":[0.000033975,0.0001069102,0.00001609474,0.00007740904,0.00001852843,0.000007903522,0.00001404227,0.00004668367,1.643041e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005455371,"about_ca_system_score_gemma":0.000009842609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003059826,"about_ca_topic_score_gemma":1.751948e-7,"domain_scores_codex":[0.999478,0.00004545761,0.0001358291,0.0001761091,0.00006239019,0.0001022605],"domain_scores_gemma":[0.9997942,0.00000628206,0.00005696955,0.00005287667,0.0000470138,0.00004263261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003591383,0.00002042415,0.0000148934,0.00004961481,0.000009817414,5.797367e-8,0.0000191134,0.003126598,0.99519,0.0003552062,0.000001853995,0.001176467],"study_design_scores_gemma":[0.000435309,0.0002662374,0.0003968757,0.00003923308,0.000007174337,0.000007861041,6.691702e-7,0.1316003,0.8667715,0.00003063644,0.0003341449,0.0001099996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3942881,0.00004912233,0.6053541,0.00001093701,0.00001005564,0.0002694091,3.885183e-7,0.00001609585,0.000001800471],"genre_scores_gemma":[0.967451,0.00001079043,0.03229908,0.00001037573,0.00009431659,0.00005705449,0.00001645389,0.00001658211,0.00004429166],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5731629,"threshold_uncertainty_score":0.4359673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021941504538615,"score_gpt":0.2029845648800195,"score_spread":0.1927651498346334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}