{"id":"W2317549718","doi":"10.1093/protein/gzu052","title":"Design and characterization of a novel human Granzyme B inhibitor","year":2014,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Serpin; Granzyme B; Extracellular; Mutagenesis; Wild type; Biology; Granzyme; Immune system; Mutant; Cell biology; Genetics; T cell; Perforin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876927,0.0004394643,0.0003771416,0.0001825683,0.0001129416,0.0004671555,0.0004942818,0.0003290357,0.001030625],"category_scores_gemma":[0.0001916658,0.0001606086,0.0003036266,0.0001465131,0.0001390663,0.0001782844,0.0001685512,0.0006296631,0.0006464364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00045389,"about_ca_system_score_gemma":0.0003887239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005228546,"about_ca_topic_score_gemma":0.0004470763,"domain_scores_codex":[0.9998727,0.00001634546,0.00001340493,0.00003148724,0.00004470273,0.00002139767],"domain_scores_gemma":[0.9999275,0.000007566365,0.00001995258,0.000005491922,0.00001318037,0.00002624443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002114262,0.0001373905,0.0001818498,0.0000661606,0.00002537578,0.0001121682,0.00001184937,0.001018122,0.9872918,0.0002884773,0.0002114199,0.01044394],"study_design_scores_gemma":[0.0001905801,0.0007520929,0.0005610663,0.000009281094,0.00005564867,0.0006747558,0.000008549428,0.004684481,0.9710014,0.00005924866,0.02199322,0.000009774905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8667994,0.0135202,0.1071559,0.0006867932,0.0001940887,0.001046938,0.001006412,0.0004511726,0.009139034],"genre_scores_gemma":[0.9084967,0.008208435,0.07055924,0.0004239474,0.00005335038,0.0004181161,0.00286276,0.0001011456,0.008876286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030625,"threshold_uncertainty_score":0.003447771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01021941504538615,"score_gpt":0.2029845648800195,"score_spread":0.1927651498346334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}