{"id":"W2317613600","doi":"10.1038/nm.4079","title":"RNA interference–induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice","year":2016,"lang":"en","type":"article","venue":"Nature Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"RNA interference; Small hairpin RNA; microRNA; Gene knockdown; Small interfering RNA; Gene isoform; Biology; RNA; Gene; Cell biology; Molecular biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005328905,0.001514515,0.0006887292,0.001811294,0.000490793,0.0008178225,0.000752835,0.001276636,0.002506153],"category_scores_gemma":[0.0002762013,0.0009461513,0.001053464,0.0004765091,0.001152339,0.0006256677,0.0003745413,0.002277551,0.001147311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007224959,"about_ca_system_score_gemma":0.0005095369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006309506,"about_ca_topic_score_gemma":0.001085511,"domain_scores_codex":[0.9993159,0.0000917846,0.00008666041,0.000204695,0.0001740557,0.0001269768],"domain_scores_gemma":[0.9992692,0.00006838993,0.0003735949,0.00007152066,0.00004106118,0.0001762739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004539784,0.00007990713,0.0001680552,0.00002544761,0.00001489327,0.0001108876,0.00001688648,0.00008810515,0.9978712,0.0003531808,0.00007298603,0.0007445842],"study_design_scores_gemma":[0.0001574397,0.0007551882,0.001574537,0.0000128627,0.00006729668,0.0004855054,0.00002824683,0.0009685376,0.9941596,0.0002306562,0.001544929,0.00001531985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792356,0.001510392,0.01222569,0.0008694176,0.0001802536,0.000133322,0.001769382,0.001221383,0.002854455],"genre_scores_gemma":[0.9753994,0.001496061,0.009177637,0.0003714996,0.00007164445,0.0002973613,0.001725738,0.0004201538,0.01104055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002506153,"threshold_uncertainty_score":0.008383989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819038411885455,"score_gpt":0.2458872476891745,"score_spread":0.2360682092772891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}