{"id":"W2317613600","doi":"10.1038/nm.4079","title":"RNA interference–induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice","year":2016,"lang":"en","type":"article","venue":"Nature Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"RNA interference; Small hairpin RNA; microRNA; Gene knockdown; Small interfering RNA; Gene isoform; Biology; RNA; Gene; Cell biology; Molecular biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002680086,0.0001577301,0.0003046217,0.00005714533,0.00002106309,0.000001711607,0.0005060068,0.0003680713,0.00003187353],"category_scores_gemma":[0.000888541,0.00007876735,0.00009251187,0.0001322587,0.0002059814,0.000004486026,0.0001360384,0.0002282766,0.00000268726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000213262,"about_ca_system_score_gemma":0.00005783666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005300047,"about_ca_topic_score_gemma":0.001232039,"domain_scores_codex":[0.9988378,0.00005330286,0.0004617531,0.0003021076,0.0001733675,0.0001717271],"domain_scores_gemma":[0.9989567,0.0001201747,0.0002626673,0.0004759579,0.0001465118,0.00003798327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008867328,0.00007432354,0.003564991,0.00001556985,0.00004366368,0.000002433658,0.0001958248,1.817061e-7,0.9915982,0.000009076123,0.001369659,0.002239368],"study_design_scores_gemma":[0.002788579,0.0003036085,0.01810798,0.0007717648,0.00001962496,0.000003295746,0.00007631521,0.000004256354,0.9761777,0.0000908119,0.001559168,0.00009690673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995132,0.0007946627,0.00003629938,0.00269437,0.0003767226,0.000155755,0.0001261565,0.000003419821,0.0006805669],"genre_scores_gemma":[0.9988387,0.0003139102,0.00003380598,0.0004058495,0.0001895371,0.000004743521,0.00002003046,0.000009885088,0.0001835928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01542048,"threshold_uncertainty_score":0.3212039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009819038411885455,"score_gpt":0.2458872476891745,"score_spread":0.2360682092772891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}