{"id":"W2317752050","doi":"10.1016/j.clpt.2005.12.064","title":"PI-43Gene expression in human mononuclear cells in response to reactive sulfonamide metabolites","year":2006,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Medical Imaging and Pathology Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Peripheral blood mononuclear cell; Gene expression; Apoptosis; Molecular biology; Gene; Jurkat cells; RNA; Metabolite; Chemistry; Biology; Pharmacology; Immune system; Biochemistry; Immunology; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001309612,0.0001546194,0.0002459419,0.0003569169,0.0002385645,0.0002963784,0.00006476682,0.0002611652,0.002128197],"category_scores_gemma":[0.0001685192,0.0001206048,0.0001232965,0.0003174991,0.0001467105,0.00006369907,0.0001123665,0.0001761465,0.0004534305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462203,"about_ca_system_score_gemma":0.0001114681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004786678,"about_ca_topic_score_gemma":0.0006058979,"domain_scores_codex":[0.9998317,0.00002355001,0.000006651639,0.00006058671,0.00004742738,0.00003006858],"domain_scores_gemma":[0.9999382,0.00001331162,0.00001551403,0.000005601102,0.00001206637,0.00001531502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008853267,0.0000450633,0.008707319,0.00005215508,0.00001607982,0.0002153679,0.0001392432,0.00004776899,0.9862303,0.00003436192,0.0001392923,0.003487674],"study_design_scores_gemma":[0.00009700379,0.001834005,0.5391815,0.00002355379,0.0001173328,0.002682356,0.0006345505,0.000936771,0.4487881,0.0002659559,0.005424459,0.00001441383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967134,0.001096979,0.0006094864,0.0000489011,0.00001550242,0.00001939587,0.0005941337,0.00002128639,0.0008810429],"genre_scores_gemma":[0.9942016,0.0008110826,0.00132296,0.000101706,0.00002565877,0.0001133902,0.0009149571,0.000009586318,0.002499162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128197,"threshold_uncertainty_score":0.007119477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08365145022968416,"score_gpt":0.4476752811007906,"score_spread":0.3640238308711065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}