{"id":"W2317767830","doi":"10.1158/0008-5472.sabcs-77","title":"BCIRG 005 main efficacy analysis: a phase III randomized trial comparing docetaxel in combination with doxorubicin and cyclophosphamide (TAC) versus doxorubicin and cyclophosphamide followed by docetaxel (AC→T) in women with Her-2/neu negative axillary lymph node positive early breast cancer.","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Saint-Sacrement; William Osler Health System","funders":"","keywords":"Medicine; Docetaxel; Internal medicine; Anthracycline; Febrile neutropenia; Breast cancer; Neutropenia; Cyclophosphamide; Regimen; Mucositis; Clinical endpoint; Metastatic breast cancer; Chemotherapy; Gastroenterology; Doxorubicin; Cancer; Oncology; Surgery; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001724444,0.0006219466,0.002393825,0.001102807,0.0002743369,0.0001442391,0.0002261762,0.0002193172,0.0001474352],"category_scores_gemma":[0.00009162109,0.0004889577,0.0001329452,0.003147416,0.0008136116,0.0003993099,0.00009702091,0.0009286814,0.000001881008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002803193,"about_ca_system_score_gemma":0.0009070759,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02783949,"about_ca_topic_score_gemma":0.004662532,"domain_scores_codex":[0.9947554,0.0008696524,0.0008431103,0.001191942,0.001003834,0.001336046],"domain_scores_gemma":[0.9972172,0.001225923,0.0003160422,0.0003741277,0.0002939847,0.0005727443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9477932,0.00209731,0.02842365,0.00007467206,0.002410776,0.0006006403,0.005596985,0.0003887439,0.006526337,0.00003875503,0.0001998441,0.005849069],"study_design_scores_gemma":[0.8515703,0.003497784,0.1372596,0.0006032494,0.001135123,0.00003075103,0.0009652709,0.0008638806,0.003498647,0.00006353911,0.00002819548,0.0004836372],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848313,0.006552578,0.00002543633,0.002732814,0.0001168614,0.005025505,0.0001566245,0.00005277513,0.0005060655],"genre_scores_gemma":[0.9924546,0.004728531,0.00007030152,0.0003603108,0.0001280533,0.001758596,0.00009508703,0.00005891931,0.0003456333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1088359,"threshold_uncertainty_score":0.9997562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207255447226454,"score_gpt":0.3666933726283754,"score_spread":0.3446208181561108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}