{"id":"W2317783713","doi":"10.1002/dvdy.24047","title":"Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit","year":2014,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Institute of Genetics; Institute of Zoology, Chinese Academy of Sciences; RIKEN; Feinberg School of Medicine; University of California, San Francisco; University of California, Santa Barbara; National Institutes of Health; Tokyo Metropolitan University; Technion-Israel Institute of Technology; University of Tokushima; Genome Institute of Singapore; Wakayama Medical University; Chinese Academy of Sciences; University of Queensland; Monash University; National Cancer Institute; University of Bristol; School of Medicine; Newcastle University; University of Dundee; University of South Florida; University of Oxford; Brigham Young University; University College London; Cancer Research UK; Wellcome Trust; National Tsing Hua University; Montana State University; University of Illinois at Urbana-Champaign; University of Dayton; Massachusetts General Hospital; University of Minnesota; Case Western Reserve University; University of Arizona; Northwestern University; University of Miami; Stowers Institute for Medical Research; University of South Carolina; Cincinnati Children's Hospital Medical Center; Brown University; Harvard University; University of Washington; University of Nebraska Medical Center; University of Toronto; Yale University","keywords":"Biology; Cell cycle; Mitosis; Cell biology; Retina; Progenitor cell; Retinal ganglion cell; Ganglion; Cellular differentiation; Cell; Molecular biology; Genetics; Stem cell; Anatomy; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001256184,0.0001428358,0.0001023561,0.00008808284,0.0000937518,0.00001634772,0.0001765271,0.000129583,0.000006526626],"category_scores_gemma":[0.00001418878,0.0001191985,0.00005782099,0.0002468092,0.00006417624,0.000006999074,0.0001164189,0.00009425275,0.000002507286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005422969,"about_ca_system_score_gemma":0.00004634641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002429572,"about_ca_topic_score_gemma":0.0003106004,"domain_scores_codex":[0.9990839,0.00005325309,0.0002681627,0.0002329955,0.0001725122,0.0001891511],"domain_scores_gemma":[0.9996607,0.000002510733,0.0001401849,0.0001214414,0.00004260603,0.00003253698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006765174,0.0004988755,0.7600805,0.0001299379,0.00001633739,6.1638e-7,0.000470627,0.0000490899,0.2226338,0.0002844581,0.0001705503,0.01559761],"study_design_scores_gemma":[0.0009611605,0.0002688819,0.7083954,0.00003986052,0.00001267577,0.000004405505,0.0005672721,0.001228979,0.2870604,0.000531928,0.0006360217,0.0002929966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951675,0.00001255103,0.0002497986,0.00002846534,0.0001573851,0.0003807987,0.000003465781,0.00001262194,0.003987449],"genre_scores_gemma":[0.997548,0.00001078231,0.001515019,0.00001862556,0.00003303555,0.00004292423,0.0004549895,0.00001822223,0.0003584289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06442662,"threshold_uncertainty_score":0.4860775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003440235317455884,"score_gpt":0.2076763394192831,"score_spread":0.2042361041018272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}