{"id":"W2317783713","doi":"10.1002/dvdy.24047","title":"Induction of the ganglion cell differentiation program in human retinal progenitors before cell cycle exit","year":2014,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Institute of Genetics; Institute of Zoology, Chinese Academy of Sciences; RIKEN; Feinberg School of Medicine; University of California, San Francisco; University of California, Santa Barbara; National Institutes of Health; Tokyo Metropolitan University; Technion-Israel Institute of Technology; University of Tokushima; Genome Institute of Singapore; Wakayama Medical University; Chinese Academy of Sciences; University of Queensland; Monash University; National Cancer Institute; University of Bristol; School of Medicine; Newcastle University; University of Dundee; University of South Florida; University of Oxford; Brigham Young University; University College London; Cancer Research UK; Wellcome Trust; National Tsing Hua University; Montana State University; University of Illinois at Urbana-Champaign; University of Dayton; Massachusetts General Hospital; University of Minnesota; Case Western Reserve University; University of Arizona; Northwestern University; University of Miami; Stowers Institute for Medical Research; University of South Carolina; Cincinnati Children's Hospital Medical Center; Brown University; Harvard University; University of Washington; University of Nebraska Medical Center; University of Toronto; Yale University","keywords":"Biology; Cell cycle; Mitosis; Cell biology; Retina; Progenitor cell; Retinal ganglion cell; Ganglion; Cellular differentiation; Cell; Molecular biology; Genetics; Stem cell; Anatomy; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014088,0.0001329598,0.0001336702,0.0002452294,0.0001519129,0.0003813901,0.00008105802,0.0001595087,0.002792186],"category_scores_gemma":[0.0001888682,0.0001210955,0.0001062736,0.0001443499,0.0001149345,0.0001326718,0.0001890644,0.0002572204,0.0009149658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003247252,"about_ca_system_score_gemma":0.0003579292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001306591,"about_ca_topic_score_gemma":0.001036115,"domain_scores_codex":[0.9999281,0.000007148135,0.000004274322,0.00002811003,0.00001889524,0.00001338676],"domain_scores_gemma":[0.9999208,0.00001749567,0.00002028587,0.00001095058,0.0000156203,0.00001481189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003051326,0.00001607777,0.005072557,0.00006519979,0.000008264186,0.0001698278,0.00009890357,0.0001968077,0.9785019,0.0005840932,0.0003038932,0.01467725],"study_design_scores_gemma":[0.00002571124,0.0002729926,0.07542273,0.00003234599,0.00002418187,0.001191965,0.0001147265,0.002149792,0.9022248,0.0003501212,0.01818242,0.000008332106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831336,0.004070658,0.006621162,0.00008692164,0.00001840441,0.00003279983,0.000611306,0.0002035515,0.005221666],"genre_scores_gemma":[0.991636,0.001263905,0.003253328,0.00005083478,0.000007122972,0.00003151618,0.0006751656,0.0000357216,0.003046312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002792186,"threshold_uncertainty_score":0.009340763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003440235317455884,"score_gpt":0.2076763394192831,"score_spread":0.2042361041018272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}