{"id":"W2317784542","doi":"10.1097/00002030-200103300-00009","title":"HIV protease and reverse transcriptase variation and therapy outcome in antiretroviral-naive individuals from a large North American cohort","year":2001,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; St. Paul's Hospital","funders":"","keywords":"Resistance mutation; Protease; Reverse transcriptase; Virology; Genotyping; Population; Biology; Cohort; Protease inhibitor (pharmacology); Lentivirus; Medicine; Viral load; Genotype; Cohort study; Immunology; Internal medicine; Virus; Viral disease; Antiretroviral therapy; Genetics; Polymerase chain reaction; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005024954,0.00032255,0.0004048173,0.000507318,0.001128981,0.00063373,0.0003576758,0.0003924826,0.001331227],"category_scores_gemma":[0.001295477,0.0002715896,0.0002174059,0.0007875368,0.0003257531,0.0002462897,0.0003140602,0.0004693481,0.0002485842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008591216,"about_ca_system_score_gemma":0.000985174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1817601,"about_ca_topic_score_gemma":0.2079822,"domain_scores_codex":[0.9995767,0.00008236937,0.00002272434,0.0001063498,0.0001221046,0.00008962223],"domain_scores_gemma":[0.9992335,0.0001186746,0.000154341,0.00007001259,0.0001720327,0.0002514323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001344655,0.00003015464,0.9979395,0.000005931557,0.00004619424,0.000140696,0.0001575736,0.0000273444,0.0003161033,0.000008381254,0.0001763548,0.001017162],"study_design_scores_gemma":[0.00001235329,0.00006143137,0.9992049,0.000004149681,0.00001839275,0.0001971447,0.0001617746,0.000101353,0.0000292574,0.000007360682,0.0001988781,0.000002938706],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994356,0.00008956335,0.00002741314,0.00002754756,0.000002541259,0.000007208442,0.0002231617,0.000001342492,0.00018561],"genre_scores_gemma":[0.9992447,0.00008495907,0.00004556717,0.00003913079,0.00000583469,0.000008992257,0.0003743963,0.000001666522,0.0001947022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1817601,"threshold_uncertainty_score":0.3614044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0153423723313426,"score_gpt":0.2630079625741517,"score_spread":0.2476655902428091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}