{"id":"W2317801899","doi":"10.1039/c6dt00648e","title":"Another step toward DNA selective targeting: Ni<sup>II</sup>and Cu<sup>II</sup>complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes","year":2016,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"European Commission","keywords":"Schiff base; Ligand (biochemistry); DNA; Chemistry; Crystallography; Stereochemistry; Copper; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001832794,0.0003906214,0.0003859096,0.000111016,0.0003637541,0.00003406434,0.0002749248,0.0003046872,0.0002495238],"category_scores_gemma":[0.00004844552,0.0003197611,0.0001830739,0.0002200886,0.0002140732,0.00003112487,0.00006556442,0.0001705593,0.00001671713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003914597,"about_ca_system_score_gemma":0.0001287382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000100337,"about_ca_topic_score_gemma":0.00002651662,"domain_scores_codex":[0.9979725,0.00006034288,0.0004404897,0.0007583046,0.000232883,0.0005354936],"domain_scores_gemma":[0.9989516,0.00003010296,0.0001192982,0.0004833305,0.0001724744,0.0002431896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002379033,0.0003096913,0.0003216835,0.00008165428,0.0002142039,0.000003379442,0.001051065,0.0001656621,0.9921527,0.000006785645,0.002958391,0.002496872],"study_design_scores_gemma":[0.001279604,0.0005832162,0.0001854019,0.00006880797,0.00009593614,0.0000320674,0.0003348,0.000193937,0.9664068,0.00004657654,0.0303421,0.0004307534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809597,0.0003453086,0.01608365,0.001017559,0.00006929965,0.0004063363,0.0005495833,0.00005029715,0.0005183212],"genre_scores_gemma":[0.9904404,0.0002148997,0.003414599,0.0002284224,0.000202119,0.00008058301,0.00008125228,0.00007761063,0.005260167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02738371,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009436055069670431,"score_gpt":0.2252273119452814,"score_spread":0.215791256875611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}