{"id":"W2317840922","doi":"10.1021/bc300239a","title":"Conformational Modulation of in Vitro Activity of Cyclic RGD Peptides via Aziridine Aldehyde-Driven Macrocyclization Chemistry","year":2012,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Princess Margaret Hospital Foundation","keywords":"Chemistry; Aziridine; Cysteamine; Conjugated system; In vitro; Amine gas treating; Aldehyde; Stereochemistry; Linker; Cystamine; Residue (chemistry); Combinatorial chemistry; Biochemistry; Organic chemistry; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001734829,0.0002818169,0.0001420853,0.00009312692,0.00007160976,0.0001491358,0.0001414426,0.0001642046,0.0005796317],"category_scores_gemma":[0.0001558469,0.0000805219,0.0001413526,0.0000573137,0.0001470601,0.0001289879,0.0001059241,0.0002934061,0.0001529429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249987,"about_ca_system_score_gemma":0.0001087185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002861395,"about_ca_topic_score_gemma":0.0004688147,"domain_scores_codex":[0.9998932,0.00002399324,0.00000925894,0.00002758483,0.00002244966,0.00002347491],"domain_scores_gemma":[0.999902,0.00002728027,0.00003066092,0.00001129397,0.000009589171,0.00001920337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002968482,0.000007114092,0.00003339089,0.0000115035,0.000001813336,0.00001846565,0.000008486987,0.00009683034,0.998937,0.00005287725,0.00001223434,0.0007907159],"study_design_scores_gemma":[0.000005581488,0.0001682209,0.0003960864,8.831499e-7,0.000003352032,0.00007113988,0.000002637942,0.0003054425,0.99828,0.00001078629,0.0007528323,0.000002922203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894621,0.001658051,0.00720823,0.00008477945,0.00003274751,0.00005600545,0.0001371169,0.00008447011,0.001276511],"genre_scores_gemma":[0.9937592,0.0006473976,0.004717526,0.00003905335,0.00001037142,0.00002999162,0.0001219035,0.00001194532,0.0006625935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005796317,"threshold_uncertainty_score":0.001939058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008290558814341374,"score_gpt":0.2322064428079807,"score_spread":0.2239158839936393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}