{"id":"W2317866984","doi":"10.1021/jm501532z","title":"Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Chemistry; Potency; ADME; Pharmacology; Hepatitis C virus; Drug; Drug discovery; Tolerability; Virology; Virus; Hepacivirus; Medicine; Biochemistry; In vitro; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446189,0.0003361653,0.0002826823,0.0002396796,0.0001640757,0.0002951155,0.00024605,0.0002284361,0.001502494],"category_scores_gemma":[0.0001176245,0.0001363277,0.0001701332,0.0001213861,0.0001491264,0.0001614653,0.0001944861,0.0004613729,0.0004805539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900256,"about_ca_system_score_gemma":0.0004247166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006548951,"about_ca_topic_score_gemma":0.001677385,"domain_scores_codex":[0.9999505,0.00001094681,0.000003153734,0.000007485508,0.00001214363,0.0000157367],"domain_scores_gemma":[0.9999753,0.000002901977,0.000004822178,0.00000212706,0.000004597056,0.00001019143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008228274,0.0003218366,0.0007737064,0.0002417305,0.00003072959,0.0007903521,0.00006287901,0.002541525,0.9185036,0.002510031,0.001878306,0.07152236],"study_design_scores_gemma":[0.000640069,0.009565306,0.005470672,0.00007111491,0.000095812,0.003764308,0.00004631619,0.008586707,0.9437518,0.000639051,0.02731268,0.00005610474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621845,0.008447735,0.008203775,0.0008280664,0.0001321043,0.0002686547,0.0008490141,0.0003134021,0.01877267],"genre_scores_gemma":[0.9796289,0.004788515,0.007219211,0.0003359738,0.00003005411,0.00005180795,0.0007385111,0.00002102085,0.007186095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001502494,"threshold_uncertainty_score":0.005026281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126910970093255,"score_gpt":0.2904705084864813,"score_spread":0.2777794114771558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}